ReviewAnnals of translational medicine2017
The association between bacteria and urinary stones.
Review in Annals of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 133 citations in OpenAlex.
- Discordance between preoperative urine culture and intraoperative stone/pelvis culture as a predictor of post-PCNL sepsis: a single-center retrospective analysis for targeted antibiotic stewardship.International urology and nephrology · 2026Article
- Antimicrobial resistance patterns in UTIs in male patients with associated kidney stone disease: a descriptive study.Journal of medicine and life · 2026Observational
- Clinical features ofFrontiers in cellular and infection microbiology · 2026Article
- Analysis of 33,616 urinary stone cases: novel findings on renal transplantation impact, comorbidity profiles, and composition patterns.Frontiers in immunology · 2026Observational
- Investigating the pathogenesis of urolithiasis through gut microbiome, plasma metabolome and inflammatory proteome: a mediation Mendelian randomization study.Clinical epigenetics · 2025Article
- Harnessing microbial-derived metabolites in the urinary tract to prevent infection induced catheter encrustation.Nature communications · 2025Article
- Metabolic abnormalities in pure vs. mixed struvite stone formers: A retrospective comparative analysis utilising large language models for data extraction.BJUI compass · 2025Article
- Improved display and detection of small renal stones using photon-counting detector CT compared to conventional energy-integrating detector CT.Abdominal radiology (New York) · 2025Article
- Optimizing antibiotic duration and percutaneous nephrostomy timing in urosepsis complicated by upper ureteral stones: a retrospective study.BMC urology · 2025Article
- The Quantitative Detection of Urogenital Mycoplasmas in Men with Urolithiasis.Pathogens (Basel, Switzerland) · 2025Article
- Outpatient crystalluria: prevalence, crystal types, and associations with comorbidities and urinary tract infections at a provincial hospital.Iranian journal of microbiology · 2025Article
- Rewriting the urinary tract paradigm: the urobiome as a gatekeeper of host defense.Molecular biology reports · 2025Review
- Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review.Heliyon · 2025Review
- Rare Case ofInternational medical case reports journal · 2025Article
- A microbiota-based perspective on urinary stone disease: insights from 16S rRNA sequencing and machine learning models.Frontiers in cellular and infection microbiology · 2025Article
- Study protocol for a randomized single-center cross-over study: Dapagliflozin treatment in recurring kidney stone patients.PloS one · 2025Article
- Matched pair analysis of wide versus narrow focus during shockwave lithotripsy for urolithiasis.Urolithiasis · 2024Article
- Hydroxyproline increases inflammation and Uropathogenic E. coli (UPEC) infection in female rats.Scientific reports · 2024Article
- The direct inhibitory effects of Lactobacillus acidophilus, a commensal urinary bacterium, on calcium oxalate stone development.Microbiome · 2024Article
- Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy.Asian journal of urology · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Urinary stone disease (USD) is an increasing clinical problem in both children and adults. One in ten individuals will experience a urinary stone, yet the mechanisms responsible for urinary stones remain largely unknown. Bacteria have long been recognized to contribute to struvite urinary stones; however, the role of bacteria in the development of the more common calcium oxalate (CaOx) and calcium phosphate (CaPhos) stones has not been extensively investigated. However, several findings do indicate a possible association between urinary stones and bacteria, including the high rate of urinary tract infections (UTI) in urinary stone patients and multiple case series of culture-positive urinary stones, including stones composed of CaOx or CaPhos. New technology, such as next generation sequencing, may be used to lend additional insight regarding the association between urinary stones and bacteria. In 2015, we published the initial bacterial sequencing results from five urinary stones, from which we sequenced multiple types of bacterial DNA. Whether these bacteria are causal, disease modifying or passively present remains to be determined. However, initial exploration of underlying mechanisms for this association indicate that bacteria aggregate selectively to crystals, that their presence is associated with increased clumping of crystals, and that they stimulate incorporation of proteins into the stone matrix.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.