ArticleJournal of endometriosis and pelvic pain disorders
Impact of physical activity on pain perception in an animal model of endometriosis.
Article in Journal of endometriosis and pelvic pain disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models.Molecular human reproduction · 2025Pooled it
- Antagonizing the corticotropin-releasing hormone receptor 1 with an orally bioavailable drug reduces endometriosis pain and associated adhesions†.Biology of reproduction · 2026Article
- Neuroendocrine-Immune Axis in Endometriosis: A Review on How the Nervous System Goes Beyond Pain Perception.Biomolecules · 2025Review
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis.Molecular human reproduction · 2025Review
- Chronic Stress Blocks the Endometriosis Immune Response by Metabolic Reprogramming.International journal of molecular sciences · 2023Article
- Review
- Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?International journal of molecular sciences · 2023Review
- Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis.Physiological reports · 2021Article
- Voluntary Wheel Running Reduces Vesicle Development in an Endometriosis Animal Model Through Modulation of Immune Parameters.Frontiers in reproductive health · 2021Article
- Assessing Pain Behavioral Responses and Neurotrophic Factors in the Dorsal Root Ganglion, Serum and Peritoneal Fluid in Rat Models of Endometriosis.Journal of family & reproductive health · 2020Article
- The Link Between Stress and Endometriosis: from Animal Models to the Clinical Scenario.Reproductive sciences (Thousand Oaks, Calif.) · 2020Review
- Effects of Environmental Enrichment in Maternally Separated Rats: Age and Sex-Specific Outcomes.Frontiers in behavioral neuroscience · 2019Article
- Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis.PloS one · 2018Article
- Impact of Psychological Stress on Pain Perception in an Animal Model of Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Ovarian hormones modify anxiety behavior and glucocorticoid receptors after chronic social isolation stress.Behavioural brain research · 2017Article
- EPScientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSymptoms of endometriosis, such as pain and infertility, are considered significant sources of stress. In many chronic conditions, exercise can act as a stress buffer and influence pain perception. We tested the impact of swimming exercise on pain perception and pain receptors in an animal model of endometriosis.
methodsEndometriosis (Endo) was induced in female rats by suturing uterine horn tissue next to the intestinal mesentery. Sham rats received sutures only. Rats were exposed to swimming exercise for 7 consecutive days, while no-exercise rats were left in the home cage. Fecal pellets were counted after swimming as an index of anxiety, and serum corticosterone levels measured. Pain perception was assessed using the hot plate test for hyperalgesia and Von Frey test for allodynia. Mu-opioid receptor (MOR) and neurokinin-1 receptor expression in the spinal cord was measured by immunofluorescence.
resultsFecal pellet counts were higher in those animals that swam (p<0.05), but no significant difference in corticosterone was found. Although Endo-exercise rats had higher colonic damage (p<0.05) with more cellular infiltration, the lesions were smaller than in Endo-no exercise rats (p<0.05). Exercise did not ameliorate the hyperalgesia, whereas it improved allodynia in both groups. MOR expression was significantly higher in Endo-exercise vs. Endo-no exercise rats (p<0.01), similar to Sham-no exercise levels.
conclusionsOur results point toward beneficial effects of swimming exercise during endometriosis progression. Physical interventions might be investigated further for their ability to reduce perceived stress and improve outcomes in endometriosis.
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Registered trials
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