ArticleJoints
Pain management in total knee arthroplasty: efficacy of a multimodal opiate-free protocol.
Article in Joints. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03675971 (COPE), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
COPE: Cannabinoids to Obviate Pain Experiment After Knee Replacement
Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Review on Nerve Blocks Utilized for Perioperative Total Knee Arthroplasty Analgesia.Orthopedic reviews · 2022Article
- Knee arthroplasty for acute fractures around the knee.EFORT open reviews · 2020Review
- Article
- Revision Total Knee Arthroplasty Is Associated With Significantly Higher Opioid Consumption as Compared With Primary Total Knee Arthroplasty in the Acute Postoperative Period.Arthroplasty today · 2020Article
- Article
- Multimodal Pain Management for Major Joint Replacement Surgery.Orthopedic nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposethis study was conducted to identify the most effective method of postoperative pain management, comparing the intravenous opiate infusion protocol with the use of a single periarticular local anesthetic infiltration (LAI) in patients undergoing total knee arthroplasty (TKA) surgery.
methods50 patients submitted to TKA surgery between 2013 and 2015 were divided into two groups. Buprenorphine was administered intravenously to the patients in Group A, while the Group B patients received a single periarticular LAI (ropivacaine and ketorolac) during surgery. Pain was assessed using a visual analog scale (VAS) and the knee injury and osteoarthritis outcome score. Hemoglobin and hematocrit were measured in the early postoperative period and at 40 days post-surgery. Range of motion and inflammatory markers were also assessed. Statistical analysis was performed using Student's t-test.
resultsstudent's t-test showed no significant difference between the groups in functional outcomes or blood values, but a difference in VAS score on the day of surgery was found (p < 0.0001), in favor of Group B.
conclusionsLAI considerably reduces postoperative pain, allowing rapid mobilization and accelerating functional recovery. LEVEL OF EVIDENCE: Level I, prospective single-blind randomized trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.