Evidence map›Paper›PMID 28217311›Full record

ArticleESC heart failure2017

Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis.

Jufen Zhang, Riet Dierckx, Kevin Mohee, Andrew L Clark, John G Cleland

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  6. Efficacy and Safety of Allopurinol on Chronic Kidney Disease Progression: A Systematic Review and Meta-Analysis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jufen ZhangAcademic Cardiology, Castle Hill Hospital, Hull York Medical School, University of Hull Kingston upon Hull UK.
Riet DierckxDepartment of Cardiology, Cardiovascular Center, OLV Hospital Aalst Belgium.
Kevin MoheeAcademic Cardiology, Castle Hill Hospital, Hull York Medical School, University of Hull Kingston upon Hull UK.
Andrew L ClarkAcademic Cardiology, Castle Hill Hospital, Hull York Medical School, University of Hull Kingston upon Hull UK.
John G ClelandThe National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College London UK.
University of Hull · GBCastle Hill Hospital · GBImperial College London · GBOnze Lieve Vrouwziekenhuis Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease. However, more evidence is required. METHODS AND

resultsWe published a meta-analysis of trials conducted before 2014 examining the effects of XOI on mortality in patients with cardiovascular disease. At least two further trials (

conclusionsThis updated meta-analysis does not suggest that XOI exert a large reduction in mortality but also cannot exclude the possibility of substantial harm or benefit.

Indexed as

Cardiovascular diseaseMeta‐analysisMortalitySystematic reviewXanthine oxidase inhibition

Identifiers

PMID28217311
PMCPMC5292634
OpenAlexW2527491667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.