ArticleAnnals of medicine and surgery (2012)2017
Risk factors for perineal wound infection after abdominoperineal resection of advanced lower rectal cancer.
Article in Annals of medicine and surgery (2012), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Evaluating negative-pressure wound therapy after abdominoperineal resection: a systematic review of efficacy and technical variability.Techniques in coloproctology · 2025Pooled it
- Effect of pathological complete response after neoadjuvant chemoradiotherapy on postoperative complications of rectal cancer: a systematic review and meta-analysis.Techniques in coloproctology · 2022Pooled it
- Effectiveness and outcome of gracilis muscle flap reconstruction following perineal surgery: a retrospective single-center cohort study.Annals of medicine and surgery (2012) · 2026Article
- Preoperative Radiotherapy as a Major Risk Factor for Pelvic Abscess after Abdominoperineal Resection and Total Pelvic Exenteration: A Retrospective Study.Journal of the anus, rectum and colon · 2026Article
- Comparing Prophylactic Administration of Sulbactam/Ampicillin Versus Cefmetazole for Prevention of Perineal Wound Infection Following Abdominoperineal Resection for Rectal Cancer: A Multicenter Randomized Controlled Trial.Annals of gastroenterological surgery · 2026Article
- Prophylactic negative pressure wound therapy with Prevena™ to prevent perineal surgical site infection.Surgery today · 2025Article
- Reconsidering the Role of V-Y Fasciocutaneous Flaps in Abdominoperineal Resection Reconstruction With the Addition of a Pelvic Exclusion Mesh.Plastic and reconstructive surgery. Global open · 2025Article
- Article
- Low Hartmann's procedure versus abdominoperineal resection for rectal cancer, a propensity score matching cohort study.BMC gastroenterology · 2024Article
- Personalized Decisional Algorithms for Soft Tissue Defect Reconstruction after Abdominoperineal Resection for Low-Lying Rectal Cancers.Current oncology (Toronto, Ont.) · 2024Article
- Management of Perineal Wounds Following Pelvic Surgery.Clinics in colon and rectal surgery · 2022Review
- Surgical Site Infections in patients undergoing major oncological surgery during the COVID-19 paNdemic (SCION): A propensity-matched analysis.Journal of surgical oncology · 2022Article
- Effects of wound infection on prognosis after laparoscopic abdominoperineal resection of rectal cancer.Frontiers in oncology · 2022Article
- Continuous Negative Pressure Drainage with Intermittent Irrigation Leaded to a Risk Reduction of Perineal Surgical Site Infection Following Laparoscopic Extralevator Abdominoperineal Excision for Low Rectal Cancer.Therapeutics and clinical risk management · 2021Article
- What is the advantage of rectal amputation with an initial perineal approach for primary anorectal carcinoma?BMC surgery · 2020Article
- Excluding the ischiorectal fossa irradiation during neoadjuvant chemoradiotherapy with intensity-modulated radiotherapy followed by abdominoperineal resection decreases perineal complications in patients with lower rectal cancer.Radiation oncology (London, England) · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAbdominoperineal resection (APR) of advanced lower rectal cancer carries a high incidence of perineal wound infection. The aim of this study was to retrospectively evaluate risk factors for perineal wound infection after APR.
methodsThe study group comprised 154 patients who underwent APR for advanced lower rectal cancer in our department from January 1990 through December 2012. The following 15 variables were studied as potential risk factors for perineal wound infection: sex, age, body-mass index, American Society of Anesthesiologists score, diabetes mellitus, preoperative albumin level, preoperative hemoglobin level, neoadjuvant chemoradiotherapy(NCRT), surgical procedure (open surgery vs. laparoscopic surgery), operation time, bleeding volume, intraoperative transfusion, tumor diameter, invasion depth, and histopathological stage.
resultsAmong the 154 patients, 30 (19%) had perineal wound infection. Univariate analysis showed that a hemoglobin level of ≤11 g/dL (p = 0.001) and NCRT (p = 0.001) were significantly related to perineal wound infection. On multivariate analysis including the preoperative albumin level (≤3.5 g/dL) in addition to the above 2 variables, neoadjuvant chemoradiotherapy (NCRT) was the only independent risk factor for perineal wound infection. Perineal wound infection developed in 31% of patients who received NCRT, as compared with 10% of patients who did not receive NCRT. The relative risk of perineal infection in the former group was 4.092 as compared with the latter group (p = 0.0002).
conclusionsNCRT is a risk factor for perineal wound infection after APR in patients with advanced lower rectal cancer.
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