Evidence map›Paper›PMID 28217182›Full record

ArticleThe open neurology journal2016

Beta Blockade and Clinical Outcomes in Aneurysmal Subarachnoid Hemorrhage.

Melody M Chang, Ronak N Raval, Jessie J Southerland, Dare A Adewumi, Khaled A Bahjri, Rajeev K Samuel, Rafeek O Woods, Olaide O Ajayi, Bryan S Lee, Frank P K Hsu and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The open neurology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Systemic inflammation in hemorrhagic strokes - A novel neurological sign and therapeutic target?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Melody M ChangDepartment of Anesthesiology, Loma Linda University School of Medicine, CA, USA.
Ronak N RavalDepartment of Anesthesiology, Loma Linda University School of Medicine, CA, USA.
Jessie J SoutherlandDepartment of Anesthesiology, San Juan Regional Medical Center, USA.
Dare A AdewumiDepartment of Neurosurgery, The Greater Houston Neurosurgery Center, TX, USA.
Khaled A BahjriSchool of Public Health, Loma Linda University, CA, USA.
Rajeev K SamuelDepartment of Anesthesiology, Loma Linda University School of Medicine, CA, USA.
Rafeek O WoodsDepartment of Anesthesiology, Loma Linda University School of Medicine, CA, USA.
Olaide O AjayiDepartment of Anesthesiology, Loma Linda University School of Medicine, CA, USA.
Bryan S LeeDepartment of Neurosurgery, Cleveland Clinic Foundation, Ohio, USA.
Frank P K HsuDepartment of Neurosurgery, University of California, Irvine, USA.
Richard L Applegate IiDepartment of Anesthesiology, University of California, Davis, USA.
Ihab R DorottaDepartment of Anesthesiology, Loma Linda University School of Medicine, CA, USA.
Loma Linda University · USCleveland Clinic · USRegional Medical Center · USUniversity of California, Davis · USUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAneurysmal subarachnoid hemorrhages are frequently complicated by hypertension and neurogenic myocardial stunning. Beta blockers may be used for management of these complications. We sought to investigate sympathetic nervous system modulation by beta blockers and their effect on radiographic vasospasm, delayed cerebral infarction, discharge destination and death.

methodsRetrospective chart review of 218 adults admitted to the ICU between 8/2004 and 9/2010 was performed. Groups were identified relevant to beta blockade: 77 were never beta blocked (No/No), 123 received post-admission beta blockers (No/Yes), and 18 were continued on their home beta blockers (Yes/Yes). Records were analyzed for baseline characteristics and the development of vasospasm, delayed cerebral infarction, discharge destination and death, expressed as adjusted odds ratio.

resultsOf the 218 patients 145 patients developed vasospasm, 47 consequently infarcted, and 53 died or required care in a long-term facility. When compared to No/No patients, No/Yes patients had significantly increased vasospasm (OR 2.11 (1.06-4.16)). However, these patients also had significantly fewer deaths or need for long term care (OR 0.17 (0.05-0.64)), with decreased tendency for infarcts (OR 0.70 (0.32-1.55)). When compared to No/No patients, Yes/Yes patients demonstrated a trend toward increased vasospasm (OR 1.61 (0.50-5.29)) that led to infarction (OR 1.51 (0.44-5.13)), but with decreased mortality or need for long term care in a facility (OR 0.13 (0.01-1.30)).

conclusionPost-admission beta blockade in aneurysmal subarachnoid hemorrhage patients was associated with increased incidence of vasospasm. However, despite the increased occurrence of vasospasm, beta blockers were associated with improved discharge characteristics and fewer deaths.

Indexed as

aSAHBeta blockadeCT angiogramGCSSubarachnoid hemorrhage

Identifiers

PMID28217182
PMCPMC5278558
OpenAlexW2574540866

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.