Evidence map›Paper›PMID 28217089›Full record

ArticleFrontiers in human neuroscience2017

Differential Modulation of Rhythmic Brain Activity in Healthy Adults by a T-Type Calcium Channel Blocker: An MEG Study.

Kerry D Walton, Emeline L Maillet, John Garcia, Timothy Cardozo, Isaac Galatzer-Levy, Rodolfo R Llinás

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Chemical Analysis of SU-Eohyeol Pharmacopuncture and ItsInternational journal of medical sciences · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kerry D WaltonCenter for Neuromagnetism, Department of Neuroscience and Physiology, New York University School of Medicine, New York NY, USA.
Emeline L MailletCenter for Neuromagnetism, Department of Neuroscience and Physiology, New York University School of Medicine, New York NY, USA.
John GarciaCenter for Neuromagnetism, Department of Neuroscience and Physiology, New York University School of Medicine, New York NY, USA.
Timothy CardozoDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York NY, USA.
Isaac Galatzer-LevySteven and Alexandra Cohen Veterans Center for PostTraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University School of Medicine, New York NY, USA.
Rodolfo R LlinásCenter for Neuromagnetism, Department of Neuroscience and Physiology, New York University School of Medicine, New York NY, USA.
New York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1-octanol is a therapeutic candidate for disorders involving the abnormal activation of the T-type calcium current since it blocks this current specifically. Such disorders include essential tremor and a group of neurological and psychiatric disorders resulting from thalamocortical dysrhythmia (TCD). For example, clinically, the observable phenotype in essential tremor is the tremor itself. The differential diagnostic of TCD is not based only on clinical signs and symptoms. Rather, TCD incorporates an electromagnetic biomarker, the presence of abnormal thalamocortical low frequency brain oscillations. The effect of 1-octanol on brain activity has not been tested. As a preliminary step to such a TCD study, we examined the short-term effects of a single dose of 1-octanol on resting brain activity in 32 healthy adults using magnetoencephalograpy. Visual inspection of baseline power spectra revealed that the subjects fell into those with strong low frequency activity (set 2,

Indexed as

alcoholbrain rhythmic activitymagnetoencephalographyoctanolpower spectrumthalamocortical dysrhythmia

Identifiers

PMID28217089
PMCPMC5289965
OpenAlexW2585920243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.