Mutational analysis of hepatitis E virus ORF1 "Y-domain": Effects on RNA replication and virion infectivity.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed.

1. Protein palmitoylation in hepatic diseases: Functional insights and therapeutic strategies.Journal of advanced research · 2025
   Review
2. Role of microRNAs in chronic hepatitis E viral infection.Bioinformation · 2025
   Article
3. Identification of key candidates associated with chronic hepatitis E viral infection.Bioinformation · 2025
   Article
4. Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival.Journal of virology · 2023
   Article
5. [Research progress in the etiology of hepatitis type E virus].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
   Review
6. Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication.eLife · 2023
   Article
7. Characteristics and Functions of HEV Proteins.Advances in experimental medicine and biology · 2023
   Article
8. Structural aspects of hepatitis E virus.Archives of virology · 2022
   Review
9. Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure.Proceedings of the National Academy of Sciences of the United States of America · 2022
   Article
10. A Modular Hepatitis E Virus Replicon System for Studies on the Role of ORF1-Encoded Polyprotein Domains.Pathogens (Basel, Switzerland) · 2022
    Article
11. Hepatitis E genotype 3 genome: A comprehensive analysis of entropy, motif conservation, relevant mutations, and clade-associated polymorphisms.Frontiers in microbiology · 2022
    Article
12. Role of "dual-personality" fragments in HEV adaptation-analysis of Y-domain region.Journal, genetic engineering & biotechnology · 2021
    Article
13. Cellular Organelles Involved in Hepatitis E Virus Infection.Pathogens (Basel, Switzerland) · 2021
    Review
14. Structural and molecular biology of hepatitis E virus.Computational and structural biotechnology journal · 2021
    Review
15. Identification of functional cis-acting RNA elements in the hepatitis E virus genome required for viral replication.PLoS pathogens · 2020
    Article
16. Hepatitis E Virus Replication.Viruses · 2019
    Review
17. Hepatitis E Virus Genome Structure and Replication Strategy.Cold Spring Harbor perspectives in medicine · 2019
    Review
18. Analysis of Hepatitis E virus (HEV) X-domain structural model.Bioinformation · 2018
    Article
19. Molecular Analysis and Modeling of Hepatitis E Virus Helicase and Identification of Novel Inhibitors by Virtual Screening.BioMed research international · 2018
    Article

Corrections and comments

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Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

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