ArticleScientific reports2017
Intraluminal pressure patterns in the human colon assessed by high-resolution manometry.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
- First Successful Regeneration of a Structurally Native-Like Colon Using a Bioabsorbable Polymer Sheet.Annals of gastroenterological surgery · 2026Article
- A Biophysical Model of Human Colonic Motor Pattern Generation in Health and Disease.bioRxiv : the preprint server for biology · 2026Article
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- Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025Article
- Straining induced spontaneous bowel transection in a patient with incarcerated inguinal hernia with cryptorchidism: A case report.International journal of surgery case reports · 2025Article
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- Risk Assessment of Stoma Outlet Obstruction Development when a Temporary Ileostomy is Created during Rectal Cancer Surgery.Journal of the anus, rectum and colon · 2025Article
- Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility.Scientific reports · 2024Article
- Simultaneous Colonic Pressure Waves in Children and Young Adults with Gastrointestinal Motility Disorders: Artefact or Colonic Physiology?Journal of clinical medicine · 2023Article
- Is staple line reinforcement still needed on contemporary staplers? A benchtop analysis.Surgical endoscopy · 2023Article
- Computational Simulation of Colorectal Cancer Biomarker Particle Mobility in a 3D Model.Molecules (Basel, Switzerland) · 2023Article
- The Effect of Biorelevant Hydrodynamic Conditions on Drug Dissolution from Extended-Release Tablets in the Dynamic Colon Model.Pharmaceutics · 2022Article
- Total collagen content and distribution is increased in human colon during advancing age.PloS one · 2022Article
- Powering Implantable and Ingestible Electronics.Advanced functional materials · 2021Article
- The Sphincter of O'Beirne-Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia.Digestive diseases and sciences · 2021Article
- The Sphincter of O'Beirne - Part 1: Study of 18 Normal Subjects.Digestive diseases and sciences · 2021Article
- Luminal Fluid Motion Inside an In Vitro Dissolution Model of the Human Ascending Colon Assessed Using Magnetic Resonance Imaging.Pharmaceutics · 2021Article
- Gas leakage from the biopsy valve: Does it matter in the era of COVID-19?Endoscopy international open · 2021Article
- The Pressure's on: Finding the Cause of Diverticula Formation.Digestive diseases and sciences · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using High Resolution Colonic Manometry during a baseline period and in response to a meal, in 15 patients with constipation, chronically dependent on laxatives, 5 healthy volunteers and 9 patients with minor, transient, IBS-like symptoms but no sign of constipation. Simultaneous pressure waves (SPWs) were the most prominent propulsive motor pattern, associated with gas expulsion and anal sphincter relaxation, inferred to be associated with fast propagating contractions. Isolated pressure transients occurred in most sensors, ranging in amplitude from 5-230 mmHg. Rhythmic haustral boundary pressure transients occurred at sensors about 4-5 cm apart. Synchronized haustral pressure waves, covering 3-5 cm of the colon occurred to create a characteristic intrahaustral cyclic motor pattern at 3-6 cycles/min, propagating in mixed direction. This activity abruptly alternated with erratic patterns resembling the segmentation motor pattern of the small intestine. High amplitude propagating pressure waves (HAPWs) were too rare to contribute to function assessment in most subjects. Most patients, dependent on laxatives for defecation, were able to generate normal motor patterns in response to a meal.
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Registered trials
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