Evidence map›Paper›PMID 28216658›Full record

ReviewNature reviews. Microbiology2017

Timing the day: what makes bacterial clocks tick?

Carl Hirschie Johnson, Chi Zhao, Yao Xu, Tetsuya Mori

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Article
  2. Article
  3. Revitalizing the "biology" in "chronobiology".Npj biological timing and sleep · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Rhizosphere microbiomes of field-grownFrontiers in microbiology · 2025
    Article
  8. Alternative splicing ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
  11. Bacteria can anticipate the seasons: photoperiodism in cyanobacteria.bioRxiv : the preprint server for biology · 2024
    Article
  12. Alternative splicing ofbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Circadian regulation of metabolism across photosynthetic organisms.The Plant journal : for cell and molecular biology · 2023
    Review
  18. The Hypothesis of a "Living Pulse" in Cells.Life (Basel, Switzerland) · 2023
    Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carl Hirschie JohnsonDepartment of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, Tennessee 37235, USA.
Chi ZhaoDepartment of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, Tennessee 37235, USA.
Yao XuDepartment of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, Tennessee 37235, USA.
Tetsuya MoriDepartment of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, Tennessee 37235, USA.

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Circadian Programs in BacteriaR37GM067152 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2015 to 2024
$4.1M
Regulation and Significance of Sustained Circadian OscillationsR01GM107434 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2013 to 2024
$4.0M
Circadian Programs in BacteriaR01GM067152 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2003 to 2014
$3.9M
Experimental Evolution of Circadian OscillatorsR01GM088595 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2009 to 2012
$1.2M
NICHD NIH HHS U54 HD083211NIGMS NIH HHS R01 GM067152NIGMS NIH HHS R01 GM088595NIGMS NIH HHS R01 GM107434NIGMS NIH HHS R37 GM067152
6 · The paper itself

Abstract

Chronobiological studies of prokaryotic organisms have generally lagged far behind the study of endogenous circadian clocks in eukaryotes, in which such systems are essentially ubiquitous. However, despite only being studied during the past 25 years, cyanobacteria have become important model organisms for the study of circadian rhythms and, presently, their timekeeping mechanism is the best understood of any system in terms of biochemistry, structural biology, biophysics and adaptive importance. Nevertheless, intrinsic daily rhythmicity among bacteria other than cyanobacteria is essentially unknown; some tantalizing information suggests widespread daily timekeeping among Eubacteria and Archaea through mechanisms that share common elements with the cyanobacterial clock but are distinct. Moreover, the recent surge of information about microbiome-host interactions has largely neglected the temporal dimension and yet daily cycles control important aspects of their relationship.

Indexed as

Bacterial ProteinsCircadian ClocksCircadian RhythmCircadian Rhythm Signaling Peptides and ProteinsCyanobacteriaLightBacterial ProteinsCircadian Rhythm Signaling Peptides and ProteinsKaiA protein, cyanobacteriaKaiB protein, cyanobacteriaKaiC protein, cyanobacteria

Identifiers

PMID28216658
PMCPMC5696799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.