Evidence map›Paper›PMID 28216644›Full record

Trial reportInternational journal of obesity (2005)2017

Infant adiposity following a randomised controlled trial of a behavioural intervention in obese pregnancy.

N Patel, K M Godfrey, D Pasupathy, J Levin, A C Flynn, L Hayes, A L Briley, R Bell, D A Lawlor, E Oteng-Ntim and 8 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 9 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 9 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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  7. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

N PatelDivision of Women's Health, Women's Health Academic Centre, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital, London, UK.
K M GodfreyMRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
D PasupathyDivision of Women's Health, Women's Health Academic Centre, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital, London, UK.
J LevinFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
A C FlynnDivision of Women's Health, Women's Health Academic Centre, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital, London, UK.
L HayesInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
A L BrileyDivision of Women's Health, Women's Health Academic Centre, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital, London, UK.
R BellInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
D A LawlorMRC Integrative Epidemiology Unit at the University of Bristol and School of Social and Community Medicine, Bristol, UK.
E Oteng-NtimDepartment of Obstetrics and Gynaecology, Guys and St Thomas' NHS Foundation Trust, London, UK.
S M NelsonSchool of Medicine, University of Glasgow, Glasgow, UK.
S C RobsonInstitute of Cellular Medicine Uterine Cell Signalling Group Newcastle University, Newcastle, UK.
N SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
C SinghDepartment of Obstetrics and Gynaecology, Guys and St Thomas' NHS Foundation Trust, London, UK.
J WardleHealth Behaviour Research Centre, Institute of Epidemiology and Health, University College London, London, UK.
S L WhiteDivision of Women's Health, Women's Health Academic Centre, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital, London, UK.
P T SeedDivision of Women's Health, Women's Health Academic Centre, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital, London, UK.
L PostonDivision of Women's Health, Women's Health Academic Centre, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital, London, UK.
King's College London · GBNewcastle University · GBSt Thomas' Hospital · GBGuy's and St Thomas' NHS Foundation Trust · GBUniversity of Glasgow · GBLondon School of Hygiene & Tropical Medicine · GBNIHR Southampton Biomedical Research Centre · GBUniversity College London · GBUniversity of Bristol · GB

Funding

Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition.R01DK103246 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2014 to 2018
$2.2M
British Heart Foundation PG/14/33/30827British Heart Foundation RG/15/17/31749Chief Scientist Office CZB/4/680Department of Health RP-PG-0407-10452Medical Research Council MC_U147574222Medical Research Council MC_U147574226Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12013/5Medical Research Council MR/L002477/1NIDDK NIH HHS R01 DK103246
6 · The paper itself

Abstract

objectivesRandomised controlled trials are required to address causality in the reported associations between maternal influences and offspring adiposity. The aim of this study was to determine whether an antenatal lifestyle intervention, associated with improvements in maternal diet and reduced gestational weight gain (GWG) in obese pregnant women leads to a reduction in infant adiposity and sustained improvements in maternal lifestyle behaviours at 6 months postpartum. SUBJECTS AND

methodsWe conducted a planned postnatal follow-up of a randomised controlled trial (UK Pregnancies Better Eating and Activity Trial (UPBEAT)) of a complex behavioural intervention targeting maternal diet (glycaemic load (GL) and saturated fat intake) and physical activity in 1555 obese pregnant women. The main outcome measure was infant adiposity, assessed by subscapular and triceps skinfold thicknesses. Maternal diet and physical activity, indices of the familial lifestyle environment, were assessed by questionnaire.

resultsA total of 698 (45.9%) infants (342 intervention and 356 standard antenatal care) were followed up at a mean age of 5.92 months. There was no difference in triceps skinfold thickness z-scores between the intervention vs standard care arms (difference -0.14 s.d., 95% confidence interval -0.38 to 0.10, P=0.246), but subscapular skinfold thickness z-score was 0.26 s.d. (-0.49 to -0.02; P=0.03) lower in the intervention arm. Maternal dietary GL (-35.34; -48.0 to -22.67; P<0.001) and saturated fat intake (-1.93% energy; -2.64 to -1.22; P<0.001) were reduced in the intervention arm at 6 months postpartum. Causal mediation analysis suggested that lower infant subscapular skinfold thickness was partially mediated by changes in antenatal maternal diet and GWG rather than postnatal diet.

conclusionsThis study provides evidence from follow-up of a randomised controlled trial that a maternal behavioural intervention in obese pregnant women has the potential to reduce infant adiposity and to produce a sustained improvement in maternal diet at 6 months postpartum.

Indexed as

Maternal Nutritional Physiological PhenomenaPrenatal Nutritional Physiological PhenomenaAdiposityAdultBody Mass IndexChild DevelopmentDietExerciseFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleMothersObesity

Identifiers

PMID28216644
PMCPMC5482395
OpenAlexW2590902394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.