ArticleNature communications2017
Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Mechanosensory encoding of surface mechanics optimizes locomotion.Nature communications · 2026Article
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery.Microsystems & nanoengineering · 2026Article
- Prefrontal spine loss in neuropsychiatric disorders: circuit consequences for cognition.Frontiers in psychiatry · 2026Review
- Development of the rodent prefrontal cortex: circuit formation, plasticity, and impacts of early life stress.Frontiers in neural circuits · 2025Review
- Development of Prefrontal Circuits and Cognitive Abilities.Cold Spring Harbor perspectives in biology · 2024Review
- Review
- Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation.Neuron · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Loss of spines in the prelimbic cortex is detrimental to working memory in mice with early-life adversity.Molecular psychiatry · 2023Article
- Is Autonomic Nervous System Involved in the Epileptogenesis in Preterm Neonates?Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Putative cell-type-specific multiregional mode in posterior parietal cortex during coordinated visual behavior.Neuron · 2023Article
- Gamma oscillations provide insights into cortical circuit development.Pflugers Archiv : European journal of physiology · 2023Review
- Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo.Journal of neurochemistry · 2023Review
- High-Frequency Local Field Potential Oscillations May Modulate Aggressive Behaviors in Mice.Biology · 2022Article
- Article
- Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.Nature communications · 2022Article
- Spontaneous Spiking Is Governed by Broadband Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coordinated activity patterns in the developing brain may contribute to the wiring of neuronal circuits underlying future behavioural requirements. However, causal evidence for this hypothesis has been difficult to obtain owing to the absence of tools for selective manipulation of oscillations during early development. We established a protocol that combines optogenetics with electrophysiological recordings from neonatal mice in vivo to elucidate the substrate of early network oscillations in the prefrontal cortex. We show that light-induced activation of layer II/III pyramidal neurons that are transfected by in utero electroporation with a high-efficiency channelrhodopsin drives frequency-specific spiking and boosts network oscillations within beta-gamma frequency range. By contrast, activation of layer V/VI pyramidal neurons causes nonspecific network activation. Thus, entrainment of neonatal prefrontal networks in fast rhythms relies on the activation of layer II/III pyramidal neurons. This approach used here may be useful for further interrogation of developing circuits, and their behavioural readout.
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