Evidence map›Paper›PMID 28216579›Full record

ArticleInternational journal of molecular sciences2017

A Plant Proteinase Inhibitor from Enterolobium contortisiliquum Attenuates Pulmonary Mechanics, Inflammation and Remodeling Induced by Elastase in Mice.

Osmar Aparecido Theodoro-Júnior, Renato Fraga Righetti, Rafael Almeida-Reis, Bruno Tadeu Martins-Oliveira, Leandro Vilela Oliva, Carla Máximo Prado, Beatriz Mangueira Saraiva-Romanholo, Edna Aparecida Leick, Nathalia Montouro Pinheiro, Yara Aparecida Lobo and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  6. Investigating the Effects of a New Peptide, Derived from theInternational journal of molecular sciences · 2023
    Article
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  13. Review
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  17. Article
  18. The Plant Proteinase InhibitorBioMed research international · 2018
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Osmar Aparecido Theodoro-JúniorDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. osmartheodorojr@gmail.com.
Renato Fraga RighettiDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. refragar@gmail.com.
Rafael Almeida-ReisDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. dosreisrafael@gmail.com.
Bruno Tadeu Martins-OliveiraDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. brunotad@gmail.com.
Leandro Vilela OlivaDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. leandrooliva@hotmail.com.
Carla Máximo PradoDepartment of Bioscience, Federal University of Sao Paulo, 09972-270 Diadema, Brazil. cmaximoprado@gmail.com.
Beatriz Mangueira Saraiva-RomanholoDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. beatrizmsaraiva@gmail.com.
Edna Aparecida LeickDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. leick51@yahoo.com.br.
Nathalia Montouro PinheiroDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. pinheiro.nathalia@gmail.com.
Yara Aparecida LoboDepartment of Biochemistry, Federal University of São Paulo, 09972-270 Diadema, Brazil. yara.lobo@yahoo.com.br.
Mílton de Arruda MartinsDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. mmartins@usp.br.
Maria Luiza Vilela OlivaDepartment of Biochemistry, Federal University of São Paulo, 09972-270 Diadema, Brazil. olivamlv@gmail.com.
Iolanda de Fátima Lopes Calvo TibérioDepartment of Clinical Medicine, School of Medicine, University of São Paulo, 01246-903 São Paulo, Brazil. iocalvo@uol.com.br.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRHospital Sírio-Libanês · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteinase inhibitors have been associated with anti-inflammatory and antioxidant activities and may represent a potential therapeutic treatment for emphysema. Our aim was to evaluate the effects of a plant Kunitz proteinase inhibitor,

Indexed as

Airway RemodelingAnimalsBiomarkersBronchoalveolar Lavage FluidDisease Models, AnimalExtracellular MatrixFabaceaeMaleMiceMucinsOxidative StressPancreatic ElastasePlant ExtractsPneumoniaProtease InhibitorsBiomarkersMucinsPancreatic ElastasePlant ExtractsProtease InhibitorsCOPDEcTIemphysemaproteinase inhibitor

Identifiers

PMID28216579
PMCPMC5343937
OpenAlexW2588533815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.