Evidence map›Paper›PMID 28216454›Full record

ReviewAgeing research reviews2017

Protective effects of short-term dietary restriction in surgical stress and chemotherapy.

Sebastian Brandhorst, Eylul Harputlugil, James R Mitchell, Valter D Longo

Open access · greenAbstract readReview
In one paragraph

Review in Ageing research reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
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  4. Trial
  5. Review
  6. Fasting the Stem Cells to Boost their Metabolic Functions.Current stem cell research & therapy · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Intimate partner violence after cancer diagnosis: an SOS call.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  13. Beneficial effects of intermittent fasting: a narrative review.Journal of Yeungnam medical science · 2023
    Article
  14. Role of mitophagy in the hallmarks of aging.Journal of biomedical research · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Does nutrition support during chemotherapy increase long-term survival of cancer patients? Lessons from the past and future perspectives.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sebastian BrandhorstLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Eylul HarputlugilDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115 USA.
James R MitchellDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115 USA. Electronic address: jmitchel@hsph.harvard.edu.
Valter D LongoLongevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.
Harvard University · USUniversity of Southern California · US

Funding

The Role of the Glucose-regulated Protein GRP78/BiP in Stress Resistance and AginP01AG034906 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2011 to 2016
$9.3M
Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage inR01AG020642 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2003 to 2017
$4.8M
Mechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0M
Protection against renal ischemic injury by short term dietary restrictionR01AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2010 to 2014
$1.6M
Chronological Age-Dependent Genomic Instability in YeastR01AG025135 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2006 to 2010
$1.3M
Dietary restriction promotes vascular health through hydrogen sulfide-mediated angiogenesisR56AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2017 to 2017
$398k
NIA NIH HHS P01 AG034906NIA NIH HHS R01 AG020642NIA NIH HHS R01 AG025135NIA NIH HHS R01 AG036712NIA NIH HHS R56 AG036712NIDDK NIH HHS R01 DK090629
6 · The paper itself

Abstract

Reduced caloric intake including fasting, as well as the dietary composition or the timing of food intake, impact longevity, likely through a modification in the onset or the severity of chronic aging-related diseases such as cancer. As with pre- and post-operative dietary recommendations, evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting. We hypothesize that preventive dietary recommendations can help in the context of both chronic cancer treatment efficacy and the avoidance of development of secondary malignancies, as well as in the context of protection from the acute stress of surgery. In this perspective review, we will discuss the latest findings on the potential role of short-term dietary restriction in cancer treatment and improvement of surgical outcome.

Indexed as

Caloric RestrictionPreoperative CareStress, PhysiologicalAnimalsDietEnergy IntakeFastingHumansLongevityNeoplasmsSignal TransductionCalorie restrictionCancerChemotherapyDietary restrictionFastingSurgery

Identifiers

PMID28216454
PMCPMC5722209
OpenAlexW2591106972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.