Evidence map›Paper›PMID 28216435›Full record

ArticleThe Journal of allergy and clinical immunology2017

Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency.

Christina Gavino, Marija Landekic, Jibin Zeng, Ning Wu, Sungmi Jung, Ming-Chao Zhong, Alexis Cohen-Blanchet, Mélanie Langelier, Odile Neyret, Duncan Lejtenyi and 6 more

Open access · bronzeAbstract readCase ReportsLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Monogenic etiologies of persistent human papillomavirus infections: A comprehensive systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Loss of human ICOSL results in combined immunodeficiency.The Journal of experimental medicine · 2018
    Article
  8. ZAP-70 in Signaling, Biology, and Disease.Annual review of immunology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Christina GavinoInfectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montreal, Quebec, Canada.
Marija LandekicInfectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montreal, Quebec, Canada.
Jibin ZengInfectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montreal, Quebec, Canada.
Ning WuLaboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
Sungmi JungDepartment of Pathology, MUHC, Montreal, Quebec, Canada.
Ming-Chao ZhongLaboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
Alexis Cohen-BlanchetBioinformatics & Molecular Biology Core Facility, IRCM, Montreal, Quebec, Canada.
Mélanie LangelierInfectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montreal, Quebec, Canada.
Odile NeyretBioinformatics & Molecular Biology Core Facility, IRCM, Montreal, Quebec, Canada.
Duncan LejtenyiDepartment of Pediatrics, Division of Allergy & Clinical Immunology, MUHC, Montreal, Quebec, Canada.
Claudia RochefortInfectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montreal, Quebec, Canada.
Judith Cotton-MontpetitBioinformatics & Molecular Biology Core Facility, IRCM, Montreal, Quebec, Canada.
Christine McCuskerDepartment of Pediatrics, Division of Allergy & Clinical Immunology, MUHC, Montreal, Quebec, Canada.
Bruce MazerDepartment of Pediatrics, Division of Allergy & Clinical Immunology, MUHC, Montreal, Quebec, Canada.
André VeilletteLaboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montreal, Quebec, Canada.
Donald C VinhInfectious Disease Susceptibility Program, McGill University Health Centre (MUHC) and Research Institute-MUHC (RI-MUHC), Montreal, Quebec, Canada; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montreal, Quebec, Canada. Electronic address: donald.vinh@mcgill.ca.
McGill University Health Centre · CAMontreal Clinical Research Institute · CA

Funding

CIHR
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAfricaAlternative SplicingCell ProliferationConsanguinityExome SequencingGenetic TherapyHumansJurkat CellsMaleMorpholinosMutagenesis, Site-DirectedMutationPedigreeSevere Combined ImmunodeficiencySignal TransductionMorpholinosZAP70 protein, humanZAP-70 Protein-Tyrosine Kinase

Identifiers

PMID28216435
PMCPMC7126384
OpenAlexW2588053381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.