ArticleReproductive toxicology (Elmsford, N.Y.)2017
Multidrug resistance transporter-1 and breast cancer resistance protein protect against ovarian toxicity, and are essential in ovarian physiology.
Article in Reproductive toxicology (Elmsford, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Enhanced exosomes for fertility protection against chemotherapy-induced ovarian damage.NPJ Regenerative medicine · 2026Article
- Progress in characterizing ABC multidrug transporters in zebrafish.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2024Article
- Transcriptomic Analysis of the Aged Nulliparous Mouse Ovary Suggests a Stress State That Promotes Pro-Inflammatory Lipid Signaling and Epithelial Cell Enrichment.International journal of molecular sciences · 2023Article
- Osteoprotegerin, Parathyroid Hormone and Vitamin D as Effective Factors on Serum-Urine Calcium Levels in Breast Cancer Patients.Archives of Razi Institute · 2022Article
- Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure.Human reproduction (Oxford, England) · 2022Article
- Multidrug efflux transporter ABCG2: expression and regulation.Cellular and molecular life sciences : CMLS · 2021Review
- Ovarian damage from chemotherapy and current approaches to its protection.Human reproduction update · 2019Review
- Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary.Scientific reports · 2019Article
- Nitrogen mustard exposure perturbs oocyte mitochondrial physiology and alters reproductive outcomes.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Multidrug Resistance Protein 1 Deficiency Promotes Doxorubicin-Induced Ovarian Toxicity in Female Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Ovarian hormones modulate multidrug resistance transporters in the ovary.Contraception and reproductive medicine · 2018Article
- Awareness and current knowledge of breast cancer.Biological research · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Ovarian protection from chemotoxicity is essential for reproductive health. Our objective is to determine the role of ATP-dependent, Multidrug Resistance Transporters (MDRs) in this protection. Previously we identified MDR-dependent cytoprotection from cyclophosphamide in mouse and human oocytes by use of MDR inhibitors. Here we use genetic deletions in MDR1a/b/BCRP of mice to test MDR function in ovarian somatic cells and find that mdr1a/b/bcrp-/- mice had significantly increased sensitivity to cyclophosphamide. Further, estrus cyclicity and follicle distribution in mdr1a/b/bcrp-/- mice also differed from age-matched wildtype ovaries. We found that MDR gene activity cycles through estrus and that MDR-1b cyclicity correlated with 17β-estradiol surges. We also examined the metabolite composition of the ovary and learned that the mdr1a/b/bcrp-/- mice have increased accumulation of metabolites indicative of oxidative stress and inflammation. We conclude that MDRs are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
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Registered trials
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