Trial reportThe Journal of steroid biochemistry and molecular biology2017
Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy.
Trial report in The Journal of steroid biochemistry and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Vitamin D levels in early and middle pregnancy and preeclampsia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status.Nutrients · 2024Trial
- Vitamin D and Child Neurodevelopment-A Post Hoc Analysis.Nutrients · 2023Trial
- Vitamin D deficiency during late pregnancy mediates placenta-associated complications.Scientific reports · 2021Trial
- Differential regulation of a placental SAM68 and sFLT1 gene pathway and the relevance to maternal vitamin D sufficiency.Pregnancy hypertension · 2020Trial
- Effects of Maternal Vitamin D Supplementation on the Maternal and Infant Epigenome.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2018Trial
- Article
- Calcium Metabolism, Immunity and Reproduction in Early Postpartum Dairy Cows.Animals : an open access journal from MDPI · 2025Article
- The role of vitamin D deficiency in placental dysfunction: A systematic review.Metabolism open · 2025Article
- Maternal vitamin D status, fetal growth patterns, and adverse pregnancy outcomes in a multisite prospective pregnancy cohort.The American journal of clinical nutrition · 2025Article
- Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review.Frontiers in nutrition · 2025Review
- Vitamin D and Endometriosis: Is There a Mechanistic Link?Cell biochemistry and function · 2025Review
- Associations Between Prenatal Vitamin D and Placental Gene Expression.The Journal of nutrition · 2024Article
- Associations Between Prenatal Vitamin D and Placental Gene Expression.bioRxiv : the preprint server for biology · 2024Article
- Dietary supplements and vascular function in hypertensive disorders of pregnancy.Pflugers Archiv : European journal of physiology · 2023Review
- Effect of Vitamin D Supplementation on the Cerebral Placental Ratio in Pregnancy Complicated with Early Fetal Growth Restriction.Journal of clinical medicine · 2022Article
- Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome-A Review.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMaternal circulating 25-hydroxyvitamin D [25(OH)D] has been shown to optimize production of 1,25-dihydroxyvitamin D [1,25(OH)
methodsA focused analysis of placental mRNA expression related to angiogenesis, pregnancy maintenance, and vitamin D metabolism was conducted in placentas from 43 subjects enrolled in a randomized controlled trial supplementing 400IU or 4400IU of vitamin D
resultsSoluble FMS-like tyrosine kinase 1 (sFlt-1) and vascular endothelial growth factor (VEGF) gene expression was significantly downregulated in the maternal subgroup with circulating 25(OH)D ≥100ng/mL compared to the subgroup <100ng/mL. DISCUSSION: Here, we report a significant association between maternal vitamin D status and the expression of sFlt-1 and VEGF at the mRNA level. Achieving maternal circulating 25(OH)D ≥100nmoles/L suggests the impact of maternal vitamin D
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.