ArticleDevelopmental biology2017
Live-imaging analysis of germ cell proliferation in the C. elegans adult supports a stochastic model for stem cell proliferation.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The mid-pachytene transition between early and late double-strand breaks in C. elegans meiosis is conserved throughout early adulthood and coincides with a peak in recombination intermediates.G3 (Bethesda, Md.) · 2026Article
- A distributive germline restricts the spread of new mutations.bioRxiv : the preprint server for biology · 2026Article
- A role for organ level dynamics in morphogenesis of the C. elegans hermaphrodite distal tip cell.Development (Cambridge, England) · 2024Article
- Getting there in one piece: The Rac pathway prevents cell fragmentation in a nonprotrusively migrating leader cell during organogenesis.bioRxiv : the preprint server for biology · 2023Article
- Article
- Live-cell Imaging and Analysis of Germline Stem Cell Mitosis inBio-protocol · 2022Article
- Proline-specific aminopeptidase P prevents replication-associated genome instability.PLoS genetics · 2022Article
- CentTracker: a trainable, machine-learning-based tool for large-scale analyses ofMolecular biology of the cell · 2021Article
- RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.Nucleic acids research · 2021Article
- Two classes of active transcription sites and their roles in developmental regulation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- More than just a pool.eLife · 2020Article
- Quantitative cytogenetics reveals molecular stoichiometry and longitudinal organization of meiotic chromosome axes and loops.PLoS biology · 2020Article
- Recent Advances in the Genetic, Anatomical, and Environmental Regulation of theJournal of developmental biology · 2020Review
- Stem cell niche exit ineLife · 2020Article
- Biology of theGenetics · 2019Review
- The molecular basis of LST-1 self-renewal activity and its control of stem cell pool size.Development (Cambridge, England) · 2019Article
- Dynamics of Notch-Dependent Transcriptional Bursting in Its Native Context.Developmental cell · 2019Article
- Sexual dimorphism of niche architecture and regulation of theMolecular biology of the cell · 2019Article
- Live cell imaging of meiosis ineLife · 2019Article
- Developmental Control of the Cell Cycle: Insights fromGenetics · 2019Review
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2 authors.
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Abstract
The C. elegans adult hermaphrodite contains a renewable pool of mitotically dividing germ cells that are contained within the progenitor zone (PZ), at the distal region of the germline. From the PZ, cells enter meiosis and differentiate, ensuring the continued production of oocytes. In this study, we investigated the proliferation strategy used to maintain the PZ pool by using a photoconvertible marker to follow the fate of selected germ cells and their descendants in live worms. We found that the most distal pool of 6-8 rows of cells in the PZ (the distal third) behave similarly, with a fold expansion corresponding to one cell division every 6h on average. Proximal to this region, proliferation decreases, and by the proximal third of the PZ, most cells have stopped dividing. In addition, we show that all the descendants of cells in rows 3 and above move proximally and leave the PZ over time. Combining our data with previous studies, we propose a stochastic model for the C. elegans PZ proliferation, where a pool of proliferating stem cells divide symmetrically within the distal most 6-8 rows of the germline and exit from this stem cell niche occurs by displacement due to competition for limited space.
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