Observational studyAcademic radiology2017
Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers.
Observational study in Academic radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Detection of pulmonary hypertension in idiopathic pulmonary fibrosis using random forest models and automated measures of central computed tomography structures.ERJ open research · 2025Article
- Imaging the Intersection of Parenchymal Abnormalities and Pulmonary Vascular Pathways.American journal of respiratory and critical care medicine · 2024Article
- Preacinar Arterial Dilation Mediates Outcomes of Quantitative Interstitial Abnormalities in the COPDGene Study.American journal of respiratory and critical care medicine · 2024Article
- Clinical Advances in Cardiovascular Computed Tomography: From Present Applications to Promising Developments.Current cardiology reports · 2024Review
- Pulmonary hypertension associated with lung diseases.The European respiratory journal · 2024Review
- The utility of quantitative computed tomography in cohort studies of chronic obstructive pulmonary disease: a narrative review.Journal of thoracic disease · 2023Review
- Smaller Left Ventricle Size at Noncontrast CT Is Associated with Lower Mortality in COPDGene Participants.Radiology · 2020Observational
- Practical recommendations for the use of beta-blockers in chronic obstructive pulmonary disease.Expert review of respiratory medicine · 2020Review
- Article
- Updated Perspectives on Pulmonary Hypertension in COPD.International journal of chronic obstructive pulmonary disease · 2020Review
- Quantification and Significance of Pulmonary Vascular Volume in Predicting Response to Ultrasound-Facilitated, Catheter-Directed Fibrinolysis in Acute Pulmonary Embolism (SEATTLE-3D).Circulation. Cardiovascular imaging · 2019Article
- Arterial Vascular Pruning, Right Ventricular Size, and Clinical Outcomes in Chronic Obstructive Pulmonary Disease. A Longitudinal Observational Study.American journal of respiratory and critical care medicine · 2019Observational
- Imaging Advances in Chronic Obstructive Pulmonary Disease. Insights from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) Study.American journal of respiratory and critical care medicine · 2019Review
- Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort.Radiology · 2018Article
- Automated Agatston Score Computation in non-ECG Gated CT Scans Using Deep Learning.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Pulmonary quantitative CT imaging in focal and diffuse disease: current research and clinical applications.The British journal of radiology · 2018Review
- Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with β-Blocker Therapy in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2017Article
- Advances in Chronic Obstructive Pulmonary Disease Imaging.Barcelona respiratory network reviewsArticle
- Artificial Intelligence in COPD: New Venues to Study a Complex Disease.Barcelona respiratory network reviewsArticle
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
Abstract
RATIONALE AND
objectivesImaging-based assessment of cardiovascular structure and function provides clinically relevant information in smokers. Non-cardiac-gated thoracic computed tomographic (CT) scanning is increasingly leveraged for clinical care and lung cancer screening. We sought to determine if more comprehensive measures of ventricular geometry could be obtained from CT using an atlas-based surface model of the heart. MATERIALS AND
methodsSubcohorts of 24 subjects with cardiac magnetic resonance imaging (MRI) and 262 subjects with echocardiography were identified from COPDGene, a longitudinal observational study of smokers. A surface model of the heart was manually initialized, and then automatically optimized to fit the epicardium for each CT. Estimates of right and left ventricular (RV and LV) volume and free-wall curvature were then calculated and compared to structural and functional metrics obtained from MRI and echocardiograms.
resultsCT measures of RV dimension and curvature correlated with similar measures obtained using MRI. RV and LV volume obtained from CT inversely correlated with echocardiogram-based estimates of RV systolic pressure using tricuspid regurgitation jet velocity and LV ejection fraction respectively. Patients with evidence of RV or LV dysfunction on echocardiogram had larger RV and LV dimensions on CT. Logistic regression models based on demographics and ventricular measures from CT had an area under the curve of >0.7 for the prediction of elevated right ventricular systolic pressure and ventricular failure.
conclusionsThese data suggest that non-cardiac-gated, non-contrast-enhanced thoracic CT scanning may provide insight into cardiac structure and function in smokers.
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Registered trials
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