Evidence map›Paper›PMID 28215575›Full record

ArticleExperimental neurology2017

Fibronectin connecting segment-1 peptide inhibits pathogenic leukocyte trafficking and inflammatory demyelination in experimental models of chronic inflammatory demyelinating polyradiculoneuropathy.

Chaoling Dong, Kelsey M Greathouse, Rebecca L Beacham, Steven P Palladino, E Scott Helton, Eroboghene E Ubogu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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  17. Novel pathomechanisms in inflammatory neuropathies.Journal of neuroinflammation · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chaoling DongNeuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
Kelsey M GreathouseNeuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
Rebecca L BeachamNeuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
Steven P PalladinoNeuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
E Scott HeltonNeuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
Eroboghene E UboguNeuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: eeubogu@uabmc.edu.
University of Alabama at Birmingham · US

Funding

Fibronectin peptide antagonism for chronic inflammatory neuropathiesR21NS073702 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UBOGU, EROBOGHENE EKAMERENO · 2011 to 2012
$430k
NINDS NIH HHS R21 NS073702
6 · The paper itself

Abstract

The molecular determinants of pathogenic leukocyte migration across the blood-nerve barrier (BNB) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are unknown. Specific disease modifying therapies for CIDP are also lacking. Fibronectin connecting segment-1 (FNCS1), an alternatively spliced fibronectin variant expressed by microvascular endothelial cells at sites of inflammation in vitro and in situ, is a counterligand for leukocyte α

Indexed as

AgedAnimalsCell MovementElectrophysiological PhenomenaFemaleFibronectinsHumansInflammationIntercellular Signaling Peptides and ProteinsLeukocytesLeukocytes, MononuclearMaleMiddle AgedPeptidesPeripheral NervesPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingCS1 peptideFibronectinsIntercellular Signaling Peptides and ProteinsPeptidesBlood-nerve barrierChronic inflammatory demyelinating polyradiculoneuropathyFibronectin connecting segment-1IntegrinLeukocyte traffickingSpontaneous autoimmune peripheral polyneuropathy

Identifiers

PMID28215575
PMCPMC5400680
OpenAlexW2588352737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.