ArticleEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology2017
Significance of uterine corpus tumor invasion in early-stage cervical cancer.
Article in European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Exploring the significance of GNG11, LPAR1, and AGTR1 in early diagnosis and prognosis of cervical cancer: A correlative analysis with clinical characteristics.Pakistan journal of medical sciences · 2025Article
- Article
- Establishment of a Novel Risk Stratification System Integrating Clinical and Pathological Parameters for Prognostication and Clinical Decision-Making in Early-Stage Cervical Cancer.Cancer medicine · 2024Article
- Construction of refined staging classification systems integrating FIGO/T-categories and corpus uterine invasion for non-metastatic cervical cancer.Cancer medicine · 2023Article
- Recent Advances in Cervical Cancer Management: A Review on Novel Prognostic Factors in Primary and Recurrent Tumors.Cancers · 2023Review
- Prognostic Significance of Ultrasound Characteristics and Body Mass Index in Patients with Apparent Early-Stage Cervical Cancer: A Single-Center, Retrospective, Cohort Study.Diagnostics (Basel, Switzerland) · 2023Article
- Hypertension and hyperglycaemia are positively correlated with local invasion of early cervical cancer.Frontiers in endocrinology · 2023Article
- Cervical cancer invading the uterine corpus and sigmoid colon: A case report.Case reports in women's health · 2022Article
- Risk assessment in the patients with uterine cervical cancer harboring intermediate risk factors after radical hysterectomy: a multicenter, retrospective analysis by the Japanese Gynecologic Oncology Group.International journal of clinical oncology · 2022Article
- A Case of Nonpuerperal Uterine Inversion Caused by Cervical Cancer.Case reports in obstetrics and gynecology · 2022Article
- Nomogram Predicting Lymph Node Metastasis in the Early-Stage Cervical Cancer.Frontiers in medicine · 2022Article
- Uterine corpus invasion in cervical cancer: a multicenter retrospective case-control study.Archives of gynecology and obstetrics · 2021Article
- Cervical carcinoma in the setting of uterovaginal prolapse: comparing standard versus tailored management.Ecancermedicalscience · 2020Article
- Clinical analysis of HPV58-positive cervical cancer.Infectious agents and cancer · 2020Article
- Article
- Less radical surgery for women with early stage cervical cancer: Our experience on radical vaginal trachelectomy and laparoscopic pelvic lymphadenectomy.Gynecologic oncology reports · 2019Article
- Characteristics and outcomes of reproductive-aged women with early-stage cervical cancer: trachelectomy vs hysterectomy.American journal of obstetrics and gynecology · 2018Observational
- Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis.Gynecologic oncology · 2018Article
- Article
- Identifying a candidate population for ovarian conservation in young women with clinical stage IB-IIB cervical cancer.International journal of cancer · 2018Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo examine characteristics and survival outcomes of women with surgically-treated cervical cancer exhibiting uterine corpus tumor invasion.
methodsWe utilized The Surveillance, Epidemiology, and End Results Program to identify cervical cancer patients who underwent hysterectomy between 1973 and 2003. Logistic regression models were used to identify risk factors for uterine corpus tumor invasion on multivariable analysis. Association of uterine corpus tumor invasion and cause-specific survival (CSS) from cervical cancer was examined with Cox proportional hazard regression models on multivariable analysis.
resultsWe identified 837 (4.9%) cases of uterine corpus invasion and 16,237 (95.1%) cases of non-invasion. Median follow-up time was 14.0 years. There were 1642 deaths due to cervical cancer. Uterine corpus invasion was independently associated with older age, non-squamous histology, high-grade tumors, large tumor size, and nodal metastasis on multivariable analysis (all, P < 0.001). On univariable analysis, uterine corpus tumor invasion was significantly associated with decreased CSS compared to the non-invasion (5-year rates, 79.0% versus 94.5%, P < 0.001). After controlling for other significant prognostic factors, uterine corpus tumor invasion remained an independent prognostic factor for decreased CSS (adjusted-hazard ratio 1.45, 95% confidence interval 1.21-1.74). Among stage T1b cases (n = 6730), uterine corpus tumor invasion remained an independent prognostic factor for decreased CSS (adjusted-hazard ratio 1.95, 95%CI 1.47-2.60). Uterine corpus tumor invasion was significantly associated with decreased CSS in stage T1b1 disease (74.5% versus 90.7%, P < 0.001) and in stage T1b2 disease (67.0% versus 79.5%, P = 0.01).
conclusionUterine corpus tumor invasion is an independent prognostic factor for decreased survival of women with early-stage cervical cancer.
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