Evidence map›Paper›PMID 28215292›Full record

ReviewVitamins and hormones2017

Emergent Role of Coronin-1a in Neuronal Signaling.

M Martorella, K Barford, B Winkler, C D Deppmann

Abstract readReview
In one paragraph

Review in Vitamins and hormones, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Coronin1A Regulates the Trafficking of Alpha Synuclein in Microglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers.Journal of molecular medicine (Berlin, Germany) · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Actin Waves and Dynamic Patterning of the Plasma Membrane.The Yale journal of biology and medicine · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M MartorellaUniversity of Virginia, Charlottesville, VA, United States.
K BarfordUniversity of Virginia, Charlottesville, VA, United States.
B WinklerUniversity of Virginia, Charlottesville, VA, United States.
C D DeppmannUniversity of Virginia, Charlottesville, VA, United States. Electronic address: deppmann@virginia.edu.
University of Virginia · US

Funding

Organization and Function of Neuronal EndosomesR01NS083378 · NINDS · UNIVERSITY OF VIRGINIA · PI Bettina R Winckler · 2013 to 2026
$5.2M
Mechanisms of Neuronal Competition During DevelopmentR01NS072388 · NINDS · UNIVERSITY OF VIRGINIA · PI DEPPMANN, CHRISTOPHER D · 2011 to 2015
$1.7M
NINDS NIH HHS R01 NS072388NINDS NIH HHS R01 NS083378
6 · The paper itself

Abstract

The Coronin family of proteins were first noted for their role in pathogen-host interactions and for modulating actin dynamics. Recently, however, Coronins have been found in a greater variety of cell types, and novel roles for the Coronins within the nervous system have been discovered. In the immune system, Coronin-1a enables Mycobacterium tuberculosis to evade lysosomal destruction. This activity appears to be analogous to protection of the NGF-TrkA signaling endosome during sympathetic nervous system development that is required for survival signaling. Similarly, others have implicated Coronin-1a in GPCR signaling during the formation of excitatory connections in the central nervous system. Its role in multiple signaling pathways suggests that it may influence cross talk between key pathways (TrkA, GPCRs) during neurodevelopment. Here, we review the role of Coronin-1a in neural development and function.

Indexed as

Models, NeurologicalSynaptic TransmissionAnimalsAxonsEndosomesHumansMicrofilament ProteinsNerve Tissue ProteinsNeurogenesisNeuronsOrganelle BiogenesisSignal Transductioncoronin proteinsMicrofilament ProteinsNerve Tissue ProteinsCoro1aCoroninNerve growth factorNeurodevelopmentNeurotrophinsNGFReceptor tyrosine kinaseSympathetic nervous systemTrkA

Identifiers

PMID28215292
PMCPMC5667946
OpenAlexW2557526939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.