ArticleNucleic acids research1987
The yeast ROAM mutation--identification of the sequences mediating host gene activation and cell-type control in the yeast retrotransposon, Ty.
Article in Nucleic acids research, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Migration of the yeast linear DNA plasmid from the cytoplasm into the nucleus in Saccharomyces cerevisiae.Current genetics · 1995Article
- Involvement of SRE element of Ty1 transposon in TEC1-dependent transcriptional activation.Nucleic acids research · 1994Article
- Interspersion of an unusual GCN4 activation site with a complex transcriptional repression site in Ty2 elements of Saccharomyces cerevisiae.Molecular and cellular biology · 1993Article
- Characterization of trans-acting mutations affecting Ty and Ty-mediated transcription in Saccharomyces cerevisiae.Current genetics · 1991Article
- Enhancer and silencerlike sites within the transcribed portion of a Ty2 transposable element of Saccharomyces cerevisiae.Molecular and cellular biology · 1989Article
- DNA damage activates transcription and transposition of yeast Ty retrotransposons.Molecular & general genetics : MGG · 1989Article
- A region internal to the coding sequences is essential for transcription of the yeast Ty-D15 element.Molecular and cellular biology · 1989Article
- A Ty1 cell-type-specific regulatory sequence is a recognition element for a constitutive binding factor.Molecular and cellular biology · 1988Article
- Control of yeast gene expression by transposable elements: maximum expression requires a functional Ty activator sequence and a defective Ty promoter.Molecular and cellular biology · 1988Article
- Transpositional competence and transcription of endogenous Ty elements in Saccharomyces cerevisiae: implications for regulation of transposition.Molecular and cellular biology · 1988Article
- Transposon tagging using Ty elements in yeast.Genetics · 1988Article
- Upstream and downstream transcriptional control signals in the yeast retrotransposon, TY.Nucleic acids research · 1988Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When the yeast retrotransposon, Ty, integrates into the 5' flanking region of a gene it can activate the expression of that gene. At the same time the activated gene is brought under cell-type specific control such that expression is high in haploid a or alpha cells but low in a/alpha diploids. These Ty mediated mutations are known as ROAM mutations. In this study we have used a ROAM mutation created in vitro to identify the sequences within Ty that mediate this phenomenon. We show that a single activator located within the coding region of the Ty element is responsible for ROAM activation. This sequence, which is regulated by the mating type of the cell, differs from classical enhancer elements in that its activity is strictly orientation dependent. An independent activator located downstream of the ROAM sequence activated transcription only in the non-ROAM orientation. This sequence may be part of an internal promoter that controls expression of the sub-genomic 5.0kb Ty transcript.
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