ArticleCurrent genetics2017
Transcription factor Afmac1 controls copper import machinery in Aspergillus fumigatus.
Article in Current genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
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- Conserved copper regulation of the antimicrobial isocyanide brassicicolin A in Alternaria brassicicola.Fungal genetics and biology : FG & B · 2023Article
- Identification and Characterization of the Determinants of Copper Resistance in the Acidophilic FungusApplied and environmental microbiology · 2023Article
- Trace copper-mediated asexual developmentFrontiers in microbiology · 2023Article
- A novel ZnCurrent genetics · 2022Article
- Ambient Availability of Amino Acids, Proteins, and Iron Impacts Copper Resistance ofFrontiers in cellular and infection microbiology · 2022Article
- Fungal-Metal Interactions: A Review of Toxicity and Homeostasis.Journal of fungi (Basel, Switzerland) · 2021Review
- Expanded role of the Cu-sensing transcription factor Mac1p in Candida albicans.Molecular microbiology · 2020Article
- The Role of Zinc in Copper Homeostasis ofInternational journal of molecular sciences · 2020Article
- Calcineurin-Responsive Transcription Factor CgCrzA Is Required for Cell Wall Integrity and Infection-Related Morphogenesis inThe plant pathology journal · 2020Article
- Copper Homeostasis inFrontiers in microbiology · 2020Article
- New insights into copper homeostasis in filamentous fungi.International microbiology : the official journal of the Spanish Society for Microbiology · 2020Review
- Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019Review
- Synergy of Hir1, Ssn6, and Snf2 global regulators is the functional determinant of a Mac1 transcriptional switch in S. cerevisiae copper homeostasis.Current genetics · 2019Article
- Copper Utilization, Regulation, and Acquisition byInternational journal of molecular sciences · 2019Review
- Molecular Characteristics of the ConservedmSphere · 2019Article
- Copper Homeostasis inFrontiers in microbiology · 2019Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper (Cu) is an essential metal for all living organisms, although it is toxic in excess. Filamentous fungus must acquire copper from its environment for growth. Despite its essentiality for growth, the mechanisms that maintain copper homeostasis are not fully understood in filamentous fungus. To gain insights into copper homeostasis, we investigated the roles of a copper transcription factor Afmac1 in the life-threatening fungus Aspergillus fumigatus, a homolog of the yeast MAC1. We observed that the Afmac1 deletion mutant exhibited not only significantly slower growth, but also incomplete conidiation including a short chain of conidia and defective melanin. Moreover, the expressions of the copper transporters, ctrA1, ctrA2, and ctrC, and metalloreductases, Afu8g01310 and fre7, were repressed in ∆Afmac1 cells, while those expressions were induced under copper depletion conditions in wild-type. The expressions of pksP and wetA, which are, respectively, involved in biosynthesis of conidia-specific melanin and the late stage of conidiogenesis, were decreased in the ∆Afmac1 strain under minimal media condition. Taken together, these results indicate that copper acquisition through AfMac1 functions in growth as well as conidiation.
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