ArticleNeuroscience2017
Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex.
Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- What electrodes can be used to measure mu rhythm (de)synchronization in the context of speech comprehension studies? An insight from theoretical analysis.Frontiers in human neuroscience · 2026Article
- Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains.Frontiers in behavioral neuroscience · 2026Article
- The central oxytocinergic system of the prairie vole.Brain structure & function · 2024Article
- A Neuroscientist's Guide to the Vole.Current protocols · 2021Article
- Oxytocin receptor binding in the titi monkey hippocampal formation is associated with parental status and partner affiliation.Scientific reports · 2020Article
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- One cranium, two brains not yet introduced: Distinct but complementary views of the social brain.Neuroscience and biobehavioral reviews · 2020Review
- Oxytocin Receptor Binding Sites in the Periphery of the Neonatal Prairie Vole.Frontiers in neuroscience · 2019Article
- Isotocin Regulates Growth Hormone but Not Prolactin Release From the Pituitary of Ricefield Eels.Frontiers in endocrinology · 2018Article
- Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection.Neural plasticity · 2018Review
- Oxytocin in the medial prefrontal cortex attenuates anxiety: Anatomical and receptor specificity and mechanism of action.Neuropharmacology · 2017Article
- The Oxytocin-Vasopressin Pathway in the Context of Love and Fear.Frontiers in endocrinology · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in these cortical processes. However, little is known about the distribution of OT and OT receptors (OTR) within the neocortex. Using autoradiographic and neuroanatomical techniques, we characterized the cortical distribution of OT receptors (OTR) in prairie voles, a socially monogamous rodent species. We found that OTR density was low in the primary sensory areas (including primary somatosensory and auditory regions) but was quite high in association regions (including temporal and parietal association areas, and prelimbic regions). In the primary motor area as well as the temporal and parietal association areas, we observed differences in OTR density across cortical layers. Specifically, cortical layers 2/3 and 5 exhibited greater OTR density than layer 4. Our results point to a role for OT in integrating sensory and motor in the prairie vole brain, providing a complementary mechanism for the modulation of social interactions. Given the ability of early social experience and developmental manipulations of OT to affect the brain and behavior, these results suggest a novel mechanism for how OT may influence cortical organization.
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