Evidence map›Paper›PMID 28214392›Full record

Trial reportDrug and alcohol dependence2017

Reduced nicotine content cigarette advertising: How false beliefs and subjective ratings affect smoking behavior.

Melissa Mercincavage, Megan L Saddleson, Emily Gup, Angela Halstead, Darren Mays, Andrew A Strasser

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Regulatory Approaches and Implementation of Minimally Addictive Combusted Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Pooled it
  2. Nicotine Reduction in Cigarettes: Literature Review and Gap Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Switching to Progressively Reduced Nicotine Content Cigarettes in Smokers With Low Socioeconomic Status: A Double-Blind Randomized Clinical Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Young Adults' Attention to Reduced Exposure Claims in IQOS Advertising and Associations With Product Perceptions and Use Intentions.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  13. Article
  14. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melissa MercincavageCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. Electronic address: melmer@upenn.edu.
Megan L SaddlesonCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. Electronic address: msaddleson@gmail.com.
Emily GupCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. Electronic address: emily.gup@uphs.upenn.edu.
Angela HalsteadCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. Electronic address: ahals@upenn.edu.
Darren MaysDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3300 Whitehaven Street, NW, Suite 4100, Washington, DC 20007, United States. Electronic address: darren.mays@georgetown.edu.
Andrew A StrasserCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States. Electronic address: strasse3@mail.med.upenn.edu.
University of Pennsylvania · USGeorgetown University Medical Center · US

Funding

UPENN TCORS: Tobacco Product Messaging in a Complex Communication EnvironmentP50CA179546 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HORNIK, ROBERT C., LERMAN, CARYN · 2013 to 2017
$18.7M
Smoking topography and harm exposure in a new PREPR01CA120594 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STRASSER, ANDREW A · 2007 to 2011
$1.9M
Using Eye Tracking to Understand and Improve Graphic Warning Label EffectivenessR01CA180929 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STRASSER, ANDREW A · 2013 to 2016
$1.8M
Optimizing Graphic Warning Labels To Promote Cessation Among Young Adult SmokersK07CA172217 · NCI · GEORGETOWN UNIVERSITY · PI MAYS, DARREN M · 2014 to 2018
$739k
NCI NIH HHS K07 CA172217NCI NIH HHS P50 CA179546NCI NIH HHS R01 CA120594NCI NIH HHS R01 CA180929
6 · The paper itself

Abstract

introductionTobacco advertising can create false beliefs about health harms that are reinforced by product design features. Reduced nicotine content (RNC) cigarettes may reduce harm, but research has not addressed advertising influences. This study examined RNC cigarette advertising effects on false harm beliefs, and how these beliefs - along with initial subjective ratings of RNC cigarettes - affect subsequent smoking behaviors. We further explored whether subjective ratings moderate associations between false beliefs and behavior.

methodsSeventy-seven daily, non-treatment-seeking smokers (66.2% male) participated in the first 15days of a randomized, controlled, open-label RNC cigarette trial. Participants viewed an RNC cigarette advertisement at baseline before completing a 5-day period of preferred brand cigarette use, followed by a 10-day period of RNC cigarette use (0.6mg nicotine yield). Participants provided pre- and post-advertisement beliefs, and subjective ratings and smoking behaviors for cigarettes smoked during laboratory visits.

resultsViewing the advertisement increased beliefs that RNC cigarettes contain less nicotine and are healthier than regular cigarettes (p's<0.001 and 0.011), and decreased the belief that they are less likely to cause cancer (p=0.046). Neither false beliefs nor subjective ratings directly affected smoking behaviors. Significant interactions of strength and taste ratings with beliefs (p's<0.001), however, indicated that among smokers with less negative initial subjective ratings, greater false beliefs were associated with greater RNC cigarette consumption.

conclusionsSmokers may misconstrue RNC cigarettes as less harmful than regular cigarettes. These beliefs, in conjunction with favorable subjective ratings, may increase product use.

Indexed as

CultureDirect-to-Consumer AdvertisingAdultDeceptionFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedNicotineSmokingTobacco ProductsYoung AdultNicotineFalse beliefsLow nicotineReduced nicotine contentSmoking behaviorsSubjective ratingsTobacco product advertising

Identifiers

PMID28214392
PMCPMC5366263
OpenAlexW2585198960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.