Evidence map›Paper›PMID 28214389›Full record

ArticleCarbohydrate research2017

Synthesis of lacto-N-tetraose.

Kelly M Craft, Steven D Townsend

Abstract read
In one paragraph

Article in Carbohydrate research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Microbial Production of Human Milk Oligosaccharides.Molecules (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Synthesis as an Expanding Resource in Human Milk Science.Journal of the American Chemical Society · 2021
    Review
  13. Transglycosylation Activity of EngineeredInternational journal of molecular sciences · 2021
    Article
  14. Lacto-iScience · 2021
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Chemical Synthesis of Human Milk Oligosaccharides: Lacto-The Journal of organic chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kelly M CraftDepartment of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, TN, 37235, United States.
Steven D TownsendDepartment of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, TN, 37235, United States. Electronic address: steven.d.townsend@vanderbilt.edu.

Funding

Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

Human milk oligosaccharides (HMOs) are the third largest macromolecular component of breast milk and offer infants numerous health benefits, most of which stem from the development of a healthy microbiome. Characterization, quantification, and chemical derivatization of HMOs remains a frontier issue in glycobiology due to the challenge of isolating appreciable quantities of homogenous HMOs from breast milk. Herein, we report the synthesis of the human milk tetrasaccharide lacto-N-tetraose (LNT). LNT is ubiquitous in human breast milk as it is a core structure common to longer-chain HMOs and many glycolipids.

Indexed as

AcetamidesCarbohydrate ConformationCarbohydrate SequenceFemaleGlycomicsHumansMilk, HumanOligosaccharidesPyransSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAcetamideslacto-N-neotetraoseOligosaccharidesPyrans

Identifiers

PMID28214389
PMCPMC6167749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.