ArticleJournal of clinical laboratory analysis2018
The relation between international normalized ratio and mortality in acute pulmonary embolism: A retrospective study.
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Prognostic Score Model for 30-Day Mortality in Patients with Acute Pulmonary Embolism Presenting to the Emergency Department.Diagnostics (Basel, Switzerland) · 2026Article
- Padua Score and D-dimer for Pulmonary Embolism Exclusion in the Elderly.Rambam Maimonides medical journal · 2025Article
- Novel Predictors of Stroke-Associated Pneumonia: A Single Center Analysis.Frontiers in neurology · 2022Article
- Prognostic Value of International Normalized Ratio in Ischemic Stroke Patients without Atrial Fibrillation or Anticoagulation Therapy.Journal of atherosclerosis and thrombosis · 2019Article
- The association of high-normal international-normalized-ratio (INR) with mortality in patients referred for coronary angiography.PloS one · 2019Article
- The relation between international normalized ratio and mortality in acute pulmonary embolism: A retrospective study.Journal of clinical laboratory analysis · 2018Article
- The Predictive Value of the MELD Scores for In-Hospital Adverse Events in Normotensive Patients with Acute Pulmonary Embolism.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute pulmonary embolism (PE) is a serious clinical disease characterized by a high mortality rate. The aim of this study was to assess the prognostic value of international normalized ratio (INR) in acute PE patients not on anticoagulant therapy.
methodsThe study included 244 hospitalized acute PE patients who were not receiving previous anticoagulant therapy. Based on their 30-day mortality, patients were categorized as survivors or non-survivors. INR was measured during the patients' admission, on the same day as the diagnosis of PE but before anticoagulation started.
resultsThirty-day mortality occurred in 39 patients (16%). INR was higher in non-survivors than in survivors (1.3±0.4 vs 1.1±0.3, P=.003). In multivariate analysis, INR (HR: 3.303, 95% CI: 1.210-9.016, P=.020) was independently associated with 30-day mortality from PE. Inclusion of INR in a model with simplified pulmonary embolism severity index (sPESI) score improved the area under the receiver operating characteristics (ROC) curve from 0.736 (95% CI: 0.659-0.814) to 0.775 (95% CI: 0.701-0.849) (P=.028). Also, the addition of INR to sPESI score enhanced the net reclassification improvement (NRI=8.8%, P<.001) and integrated discrimination improvement (IDI=0.043, P=.027).
conclusionElevated INR may have prognostic value for 30-day mortality in acute PE patients not on anticoagulation. Combining INR with sPESI score improved the predictive value for all-cause mortality. However, further large-scale studies are needed to confirm it's prognostic role.
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