Evidence map›Paper›PMID 28213942›Full record

ArticleBritish journal of pharmacology2017

PGE

Siwei Tan, Xiaoliang Chen, Minyi Xu, Xiaoli Huang, Huiling Liu, Jie Jiang, Yu Lu, Xiaojie Peng, Bin Wu

Abstract read
In one paragraph

Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. The peripheral CBBritish journal of pharmacology · 2020
    Article
  10. Article
  11. PGEBritish journal of pharmacology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Siwei TanDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xiaoliang ChenDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Minyi XuDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xiaoli HuangDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Huiling LiuDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jie JiangDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Yu LuDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xiaojie PengDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Bin WuDepartment of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Sun Yat-sen University · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePortal hypertensive gastropathy (PHG) is a serious complication of liver cirrhosis and a potential cause of bleeding in patients with cirrhosis. Suppressed mucosal epithelial proliferation is a crucial pathological characteristic of PHG. Our studies demonstrated an important role for PGE EXPERIMENTAL APPROACH: Gastric mucosal proliferation was examined in patients with PHG and the PHG model of β-arr1-knockout (β-arr1-KO) and β-arr1-wild type (β-arr1-WT) mice. The induction of β-arr1 and EP KEY

resultsPortal hypertension suppressed COX-1 but not COX-2, which was accompanied by a down-regulation of PGE CONCLUSIONS AND IMPLICATIONS: These results indicate that β-arr1 regulates PGE

Indexed as

Animalsbeta-Arrestin 1DinoprostoneErbB ReceptorsGastric MucosaHumansHypertension, PortalMaleMiceMice, Inbred C57BLMice, KnockoutRandom AllocationReceptors, Prostaglandin E, EP4 Subtypesrc-Family KinasesArrb1 protein, mousebeta-Arrestin 1DinoprostoneEGFR protein, mouseErbB ReceptorsReceptors, Prostaglandin E, EP4 Subtypesrc-Family Kinases

Identifiers

PMID28213942
PMCPMC5386997
OpenAlexW2785754011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.