ArticleBreast cancer research and treatment2017
High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function.
Article in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Biomarker testing in advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2 negative breast cancer: expert recommendations.Therapeutic advances in medical oncology · 2026Review
- Genetic Insights into Colorectal Cancer: Evaluating PI3K/AKT Signaling Pathway Genes Expression.International journal of molecular sciences · 2024Article
- The interplay of PTEN and AKT nexus in breast cancer: a molecular perspective.Molecular biology reports · 2024Article
- Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters.Cancer biomarkers : section A of Disease markers · 2024Article
- Review
- Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms.Journal of pathology informatics · 2023Article
- PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells.Experimental and therapeutic medicine · 2021Article
- Review
- Long non-coding NR2F1-AS1 is associated with tumor recurrence in estrogen receptor-positive breast cancers.Molecular oncology · 2020Article
- The Complex Landscape ofCold Spring Harbor perspectives in medicine · 2020Review
- Hierarchical clustering of activated proteins in the PI3K and MAPK pathways in ER-positive, HER2-negative breast cancer with potential therapeutic consequences.British journal of cancer · 2018Article
- Emerging roles of long non-coding RNA in cancer.Cancer science · 2018Review
- [Role of lncRNA PTENP1 in tumorigenesis and progression of bladder cancer and the molecular mechanism].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines.Oncotarget · 2017Article
- Opposite Prognostic Impact of Single PTEN-loss andCancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePTEN is an important tumor suppressor in breast cancer. Here, we examined the prognostic and predictive value of PTEN and PTEN pseudogene (PTENP1) gene expression in patients with locally advanced breast cancer given neoadjuvant chemotherapy.
methodsThe association between pretreatment PTEN and PTENP1 gene expression, response to neoadjuvant chemotherapy, and recurrence-free and disease-specific survival was assessed in 364 patients with locally advanced breast cancer given doxorubicin, 5-fluorouracil/mitomycin, or epirubicin versus paclitaxel in three phase II prospective studies. Further, protein expression of PTEN or phosphorylated Akt, S6 kinase, and 4EBP1 was assessed in a subgroup of 187 tumors.
resultsNeither PTEN nor PTENP1 gene expression level predicted response to any of the chemotherapy regimens tested (n = 317). Among patients without distant metastases (n = 282), a high pretreatment PTEN mRNA level was associated with inferior relapse-free (RFS; p = 0.001) and disease-specific survival (DSS; p = 0.003). Notably, this association was limited to patients harboring TP53 wild-type tumors (RFS; p = 0.003, DSS; p = 0.009). PTEN mRNA correlated significantly with PTENP1 mRNA levels (r
conclusionHigh intratumoral PTEN gene expression was associated with poor prognosis in patients with locally advanced breast cancers harboring wild-type TP53.
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