Evidence map›Paper›PMID 28213757›Full record

ArticleDiabetologia2017

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.

Abby Willcox, Sarah J Richardson, Lucy S K Walker, Sally C Kent, Noel G Morgan, Kathleen M Gillespie

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PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
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  3. Review
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  5. Article
  6. Identifying the 'Achilles heel' of type 1 diabetes.Clinical and experimental immunology · 2021
    Review
  7. Article
  8. Review
  9. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Abby WillcoxDiabetes and Metabolism, Level 2 Learning and Research, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK.
Sarah J RichardsonInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Lucy S K WalkerInstitute of Immunity and Transplantation, UCL Division of Infection and Immunity, Royal Free Campus, London, UK.
Sally C KentDivision of Diabetes, Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA.
Noel G MorganInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Kathleen M GillespieDiabetes and Metabolism, Level 2 Learning and Research, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK. K.M.Gillespie@bristol.ac.uk.

Funding

Medical Research Council MR/N001435/1
6 · The paper itself

Abstract

aims/hypothesisPancreatic lymph nodes (PLNs) are critical sites for the initial interaction between islet autoantigens and autoreactive lymphocytes, but the histology of PLNs in tissue from individuals with type 1 diabetes has not been analysed in detail. The aim of this study was to examine PLN tissue sections from healthy donors compared with those at risk of, or with recent-onset and longer-duration type 1 diabetes.

methodsImmunofluorescence staining was used to examine PLN sections from the following donor groups: non-diabetic (n=15), non-diabetic islet autoantibody-positive (n=5), recent-onset (≤1.5 years duration) type 1 diabetes (n=13), and longer-duration type 1 diabetes (n=15). Staining for CD3, CD20 and Ki67 was used to detect primary and secondary (germinal centre-containing) follicles and CD21 and CD35 to detect follicular dendritic cell networks.

resultsThe frequency of secondary follicles was lower in the recent-onset type 1 diabetes group compared with the non-diabetic control group. The presence of insulitis (as evidence of ongoing beta cell destruction) and diagnosis of type 1 diabetes at a younger age, however, did not appear to be associated with a lower frequency of secondary follicles. A higher proportion of primary B cell follicles were observed to lack follicular dendritic cell networks in the recent-onset type 1 diabetes group. CONCLUSIONS/

interpretationHistological analysis of rare PLNs from individuals with type 1 diabetes suggests a previously unrecognised phenotype comprising decreased primary B cell follicle frequency and fewer follicular dendritic cell networks in recent-onset type 1 diabetes.

Indexed as

AdolescentAdultAgedAnimalsAutoantibodiesAutoantigensB-LymphocytesChildChild, PreschoolCohort StudiesDendritic CellsDiabetes Mellitus, Type 1FemaleGerminal CenterGoatsHumansAutoantibodiesAutoantigensInsulinKi-67 AntigenHistologyIslet autoimmunityPancreatic lymph nodesType 1 diabetes

Identifiers

PMID28213757
PMCPMC5487689

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.