Evidence map›Paper›PMID 28213729›Full record

ArticleJournal of cancer research and clinical oncology2017

Alpha tocopherol transfer protein (αTTP) is expressed in endometrial carcinoma and is correlated with FIGO stage and 5-year survival.

Sabine Heublein, Thomas Vrekoussis, Ronny Etzl, Daisy Rotzoll, Christina Kuhn, Gesine Faigle, Iordanis Navrozoglou, Theodore Stefos, Antonis Makrigiannakis, Udo Jeschke

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Sabine HeubleinDepartment of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany. sabine.heublein@med.uni-heidelberg.de.
Thomas VrekoussisDepartment of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany.
Ronny EtzlDivision of Neonatology, Department of Pediatrics, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
Daisy RotzollDivision of Gynecologic and Perinatal Pathology, Institute of Pathology, University of Leipzig, Leipzig, Germany.
Christina KuhnDepartment of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany.
Gesine FaigleDepartment of Obstetrics and Gynecology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
Iordanis NavrozoglouDepartment of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina, Greece.
Theodore StefosDepartment of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina, Greece.
Antonis MakrigiannakisDepartment of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion, Greece.
Udo JeschkeDepartment of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany.
Ludwig-Maximilians-Universität München · DEHeidelberg University · DEUniversity of Ioannina · GRLeipzig University · DEUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased oxidative stress plays an important role in cancer development. Vitamin E is considered a potent anti-oxidant and its transfer protein αTTP facilitates its cellular delivery. We hypothesize that αTTP could be present in and have an impact on endometrial cancer. MATERIALS AND

methodsIshikawa endometrial cancer cells were treated with BSO and AAPH to mimick oxidative stress conditions. αTTP was detected by immunocytochemistry and western blot. αΤΤP expression was then assessed in 191 endometrioid endometrial carcinomas. Immunopositivity was correlated with grade, FIGO stage, and 5-year survival. Immuno-reactivity was assessed with a semi-quantitative score.

resultsAAPH- and BSO-induced αTTP expression in Ishikawa cells. Immunohistochemical assessment of the 191 endometrial cancer cases showed that αTTP expression correlated with FIGO stage (p = 0.014) but not with grade. Five-year survival was significantly better in cases of lower αTTP expression compared to cases with higher expression (p = 0.041).

conclusionsThe current results show that αTTP plays a role in endometrial carcinoma. Possibly endometrial cancer cells attempt to protect themselves from increasing oxidative stress by up-regulating αTTP. Selective molecular interventions targeting oxidative stress escape strategies, e.g., by overexpression of αTTP, could, therefore, allow oxidative stress to damage cancer cell membranes and thus restrict cancer progression.

Indexed as

AmidinesButhionine SulfoximineCarrier ProteinsCell Line, TumorEndometrial NeoplasmsFemaleHumansNeoplasm StagingOxidative StressPrognosisUp-Regulation2,2'-azobis(2-amidinopropane)alpha-tocopherol transfer proteinAmidinesButhionine SulfoximineCarrier ProteinsAlpha tocopherol transfer proteinEndometrial cancerSurvival

Identifiers

PMID28213729
PMCPMC11819187
OpenAlexW2587884836

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.