Evidence map›Paper›PMID 28213620›Full record

ArticleIntensive care medicine2017

Post-contrast acute kidney injury in intensive care unit patients: a propensity score-adjusted study.

Jennifer S McDonald, Robert J McDonald, Eric E Williamson, David F Kallmes, Kianoush Kashani

Erratum issued Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05132062 (A Contemporary Simple Risk Score for Prediction of Contrast-Associated Acute Kidney Injury After Percutaneous Coronary Intervention Development and Initial Validation), which is not on this map. Cited by 48 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05132062 completednot on this map

A Contemporary Simple Risk Score for Prediction of Contrast-Associated Acute Kidney Injury After Percutaneous Coronary Intervention Development and Initial Validation

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2012 to 2021Enrolled14,616ConditionsContrast-induced NephropathyArmsPercutaneous Coronary Intervention
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
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  11. Patient radiation safety in the intensive care unit.The British journal of radiology · 2025
    Review
  12. Review
  13. Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Acute kidney injury in neurocritical care.Critical care (London, England) · 2023
    Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jennifer S McDonaldDepartment of Radiology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA. mcdonald.jennifer@mayo.edu.
Robert J McDonaldDepartment of Radiology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
Eric E WilliamsonDepartment of Radiology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
David F KallmesDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Kianoush KashaniDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the association of intravenous iodinated contrast material administration with the subsequent development of post-contrast AKI (PC-AKI), emergent dialysis, and short-term mortality using a propensity score-adjusted analysis of a cohort of intensive care unit (ICU) patients who underwent CT examination.

methodsAll ICU patients at our institution who received a contrast-enhanced (contrast group) or unenhanced (noncontrast group) CT scan from January 2006 to December 2014 were identified. Patients were subdivided into pre-CT eGFR > 45 and eGFR ≤ 45 subsets and separately underwent propensity score analysis. Rates of KDIGO-defined AKI, dialysis, and mortality were compared between contrast and noncontrast groups. Separate analyses of eGFR ≥ 60, 30-59, and <30 subsets were also performed.

resultsA total of 6877 ICU patients (4351 contrast, 2526 noncontrast) were included in the study. Following propensity score adjustment, the rates of AKI (31 vs. 34%, OR .88 (95% CI .75-1.05), p = .15), dialysis (2.0 vs. 1.7%, OR 1.20 (.66-2.17), p = .55), and mortality (12 vs. 14%, OR .87 (.69-1.10), p = .23) were not significantly higher in the contrast versus noncontrast group in the matched eGFR > 45 subset. Significantly higher rates of dialysis (6.7 vs. 2.5%, OR 2.72 (1.14-6.46), p = .0240) were observed in the contrast versus noncontrast group in the matched eGFR ≤ 45 subset.

conclusionsIntravenous contrast material administration was not associated with an increased risk of AKI, emergent dialysis, and short-term mortality in ICU patients with pre-CT eGFR > 45. An increased risk of dialysis was observed in patients with pre-CT eGFR ≤ 45.

Indexed as

Acute Kidney InjuryAdministration, IntravenousAdultAgedAged, 80 and overCohort StudiesContrast MediaCritical CareFemaleHumansIntensive Care UnitsIodineMaleMiddle AgedPropensity ScoreRenal DialysisContrast MediaIodineAKIIodinated contrast materialPost-contrast acute kidney injury

Identifiers

PMID28213620

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.