Evidence map›Paper›PMID 28213473›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Central role of T helper 17 cells in chronic hypoxia-induced pulmonary hypertension.

Levi D Maston, David T Jones, Wieslawa Giermakowska, Tamara A Howard, Judy L Cannon, Wei Wang, Yongyi Wei, Weimin Xuan, Thomas C Resta, Laura V Gonzalez Bosc

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Roles of the Altitude-Adapted Immune Microenvironment in Pulmonary Vascular Remodeling in High-Altitude Pulmonary Hypertension: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Vascular Remodeling: The Multicellular Mechanisms of Pulmonary Hypertension.International journal of molecular sciences · 2025
    Review
  14. Article
  15. Intrapulmonary T Cells Are Sufficient forInternational journal of molecular sciences · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Levi D MastonVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
David T JonesVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Wieslawa GiermakowskaVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Tamara A HowardVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Judy L CannonDepartment of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, New Mexico; and.
Wei WangDepartment of Chemistry, University of New Mexico, Albuquerque, New Mexico.
Yongyi WeiDepartment of Chemistry, University of New Mexico, Albuquerque, New Mexico.
Weimin XuanDepartment of Chemistry, University of New Mexico, Albuquerque, New Mexico.
Thomas C RestaVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Laura V Gonzalez BoscVascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico; lgonzalezbosc@salud.unm.edu.
University of New Mexico · US

Funding

MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM (T32)T32HL007736 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 1993 to 2025
$6.5M
Pulmonary Vasoreactivity Following Chronic HypoxiaR01HL088192 · NHLBI · UNIVERSITY OF NEW MEXICO · PI RESTA, THOMAS C · 2008 to 2012
$1.9M
The role of PKCtheta in T cell and T-ALL migrationR01AI097202 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANNON, JUDY LIN · 2012 to 2016
$1.9M
Vascular Smooth Muscle Signaling in Intermittent Hypoxia-Induced Pulmonary HypertensionR01HL132883 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 2016 to 2019
$1.5M
The Role of Adaptive Immunity in Chronic Hypoxia-Induced Pulmonary HypertensionF30HL123109 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MASTON, LEVI DAVID · 2014 to 2017
$93k
NHLBI NIH HHS F30 HL123109NHLBI NIH HHS R01 HL088192NHLBI NIH HHS R01 HL132883NHLBI NIH HHS T32 HL007736NIAID NIH HHS R01 AI097202
6 · The paper itself

Abstract

Inflammation is a prominent pathological feature in pulmonary arterial hypertension, as demonstrated by pulmonary vascular infiltration of inflammatory cells, including T and B lymphocytes. However, the contribution of the adaptive immune system is not well characterized in pulmonary hypertension caused by chronic hypoxia. CD4

Indexed as

Adoptive TransferAnimalsBlood PressureCD8-Positive T-LymphocytesCell CountCell MovementChronic DiseaseFemaleHeart VentriclesHomeodomain ProteinsHypertension, PulmonaryHypoxiaInterleukin-17Interleukin-6LungLymphocyte DepletionHomeodomain ProteinsInterleukin-17Interleukin-6RAG-1 proteinRNA, MessengerCD4 T cellsinflammationinterleukin-6retinoid-related orphan receptor-γτSR1001

Identifiers

PMID28213473
PMCPMC5451600
OpenAlexW2588339628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.