Evidence map›Paper›PMID 28213470›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.

Carolyn M Hendrickson, Jason Abbott, Hanjing Zhuo, Kathleen D Liu, Carolyn S Calfee, Michael A Matthay, NHLBI ARDS Network

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Activation of donor-derived eosinophils during static storage contributes to primary graft dysfunction after lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
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  9. Observational
  10. The ex vivo perfused human lung is resistant to injury by high-doseAmerican journal of physiology. Lung cellular and molecular physiology · 2020
    Article
  11. α-Tocopherol Attenuates the Severity ofAmerican journal of respiratory cell and molecular biology · 2020
    Article
  12. Article
  13. Biomarkers in pediatric acute respiratory distress syndrome.Annals of translational medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Carolyn M HendricksonDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California; carolyn.hendrickson@ucsf.edu.
Jason AbbottDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California.
Hanjing ZhuoDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California.
Kathleen D LiuCardiovascular Research Institute, University of California, San Francisco, San Francisco, California.
Carolyn S CalfeeDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California.
Michael A MatthayDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California.
NHLBI ARDS Network
University of California, San Francisco · US

Funding

MUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6M
MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCER01HL051854 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 1994 to 2012
$4.4M
Resolution of Clinical Lung InjuryR37HL051856 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2006 to 2015
$3.9M
Cigarette Smoke Exposure and Acute Lung Injury After Severe Blunt TraumaR01HL110969 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2012 to 2016
$1.9M
Acute Respiratory Distress Syndrome after Isolated Traumatic Brain Injury: Platelet Biology, Endothelial Activation, and Mechanical VentilationK23HL133495 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENDRICKSON, CAROLYN MARIE · 2016 to 2020
$994k
Molecular Endotypes of ARDS: Identification, Biology, and Differential Response to TherapyR01HL131621 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2016 to 2017
$806k
ARDS Endotypes: Expanded Analysis of Clinical and Biological Phenotypes and Evolution Over TimeK24HL133390 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2016 to 2017
$241k
The Risk of Acute Respiratory Distress Syndrome after Severe Isolated Traumatic BF32HL124911 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENDRICKSON, CAROLYN MARIE · 2014 to 2015
$125k
NHLBI NIH HHS F32 HL124911NHLBI NIH HHS K23 HL133495NHLBI NIH HHS K24 HL133390NHLBI NIH HHS R01 HL051854NHLBI NIH HHS R01 HL110969NHLBI NIH HHS R01 HL131621NHLBI NIH HHS R37 HL051856NHLBI NIH HHS T32 HL007185
6 · The paper itself

Abstract

The protein concentration of alveolar edema fluid in acute respiratory distress syndrome (ARDS) is dynamic. It reflects alveolar flooding during acute injury, as well as fluid and protein clearance over time. We hypothesized that among ARDS patients treated with low tidal volume ventilation, higher concentrations of protein in mini-bronchoalveolar lavage (mBAL) samples would predict slower resolution of lung injury and worse clinical outcomes. Total protein and IgM concentrations in

Indexed as

Ventilators, MechanicalBiomarkersBronchoalveolar Lavage FluidFemaleHumansImmunoglobulin MLinear ModelsLung InjuryMaleMiddle AgedProteinsRespiratory Distress SyndromeTreatment OutcomeBiomarkersImmunoglobulin MProteinsacute respiratory distress syndromealveolar fluid clearanceimmunoglobulin Mmini-bronchoalveolar lavage

Identifiers

PMID28213470
PMCPMC5451593
OpenAlexW2588864840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.