Evidence map›Paper›PMID 28213124›Full record

ArticleJournal of affective disorders2017

Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism.

Arpana Agrawal, Rebecca Tillman, Richard A Grucza, Elliot C Nelson, Vivia V McCutcheon, Lauren Few, Kenneth R Conner, Michael T Lynskey, Danielle M Dick, Howard J Edenberg and 7 more

Abstract read
In one paragraph

Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Intersection of adverse childhood experiences, suicide and overdose prevention.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Mental Health and Smoking-Related Determinants of Alcohol Drinking Experience in Korean Adolescents.International journal of environmental research and public health · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Neuroimmune signaling in alcohol use disorder.Pharmacology, biochemistry, and behavior · 2019
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Arpana AgrawalWashington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA. Electronic address: arpana@wustl.edu.
Rebecca TillmanWashington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA.
Richard A GruczaWashington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA.
Elliot C NelsonWashington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA.
Vivia V McCutcheonWashington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA.
Lauren FewWashington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA.
Kenneth R ConnerUniversity of Rochester Medical Center, Dept. of Emergency Medicine, Rochester, NY, USA.
Michael T LynskeyKings College, Institute of Psychiatry, Dept. of Addiction, London, UK.
Danielle M DickVirginia Commonwealth University, Dept. of African-American Studies, Richmond, VA, USA.
Howard J EdenbergIndiana University, Dept. of Biochemistry and Molecular Biology, Indianapolis, IN, USA.
Victor M HesselbrockUniversity of Connecticut Health, Dept. of Psychiatry, Farmington, CT, USA.
John R KramerUniversity of Iowa Carver College of Medicine, Dept. of Psychiatry - Div. of Psychology, Iowa City, IA, USA.
Samuel KupermanUniversity of Iowa Carver College of Medicine, Depts. of Psychiatry and Pediatrics, Iowa City, IA, USA.
John I NurnbergerIndiana University School of Medicine, Dept. of Psychiatry, Indianapolis, IN, USA.
Marc A SchuckitUniversity of California San Diego, Dept. of Psychiatry, San Diego, CA, USA.
Bernice PorjeszSUNY Downstate Medical Center, Dept. of Psychiatry, Brooklyn, NY, USA.
Kathleen K BucholzWashington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7M
CANNABIS, DEPRESSION AND SUICIDAL THOUGHTS AND BEHAVIORSR01DA040411 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, GRUCZA, RICHARD A · 2015 to 2017
$1.1M
DELINEATING THE ROLE OF GENETIC INFLUENCES ON CANNABIS INVOLVEMENTK02DA032573 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA · 2012 to 2021
$1.1M
SMOKING, SUICIDE AND MENTAL HEALTH: USING POLICY CHANGE TO PROBE CAUSALITYR01DA042195 · NIDA · WASHINGTON UNIVERSITY · PI GRUCZA, RICHARD A · 2016 to 2018
$676k
NIAAA NIH HHS U10 AA008401NIDA NIH HHS K02 DA032573NIDA NIH HHS R01 DA040411NIDA NIH HHS R01 DA042195
6 · The paper itself

Abstract

backgroundSubstance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders.

methodsThe prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt.

resultsIdeation was related to 0.71-0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44-1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. LIMITATIONS: The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias.

conclusionSuicide attempts are associated with increased likelihood of onset of substance dependence.

Indexed as

Suicidal IdeationAdolescentAlcohol DrinkingAlcoholismChildCross-Sectional StudiesFamily HealthFemaleHumansMajor Depressive DisorderMaleMarijuana AbuseMarijuana SmokingProspective StudiesSmokingSuicide, AttemptedAlcoholAttemptCannabisCOGAIdeationNicotineSuicide

Identifiers

PMID28213124
PMCPMC5434702

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.