Evidence map›Paper›PMID 28212617›Full record

ArticleBMC nephrology2017

Surfactant protein-D (SP-D) gene polymorphisms and serum level as predictors of susceptibility and prognosis of acute kidney injury in the Chinese population.

Jiao Liu, Guang Li, Lianghai Li, Zhiyong Liu, Qingshan Zhou, Guirong Wang, Dechang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. The role of regulatory T cells in the pathogenesis of acute kidney injury.Journal of cellular and molecular medicine · 2023
    Article
  2. Review
  3. Article
  4. Genetic Susceptibility to Acute Kidney Injury.Journal of clinical medicine · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Collectins in urinary tract and kidney diseases.International urology and nephrology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Jiao LiuDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Guang LiDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Lianghai LiDepartment of Critical Care Medicine, Jingzhou Central Hospital, Jingzhou, Hubei, 434020, China.
Zhiyong LiuDepartment of Internal medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Qingshan ZhouDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Guirong WangDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
Dechang ChenDepartment of Critical Care Medicine, Shanghai Ruijin Hospital Affiliated with Jiaotong University, Shanghai, China. 18918520002@189.cn.
Renmin Hospital of Wuhan University · CNWuhan University · CNJingzhou Central Hospital · CNRuijin Hospital · CNSUNY Upstate Medical University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInjury to the kidney epithelial barrier is a characteristic feature of acute kidney injury (AKI). Serum surfactant protein-D (SP-D), a known biomarker of damaged alveolar epithelium, is also secreted by renal tubular epithelial cells. Therefore, the aim of this study was to examine the possible association of SP-D with AKI susceptibility and prognosis.

methodsIn this study, 159 AKI patients and 120 healthy individuals were included. SP-D polymorphisms Thr11Met and Thr160Ala, AKI patient serum SP-D levels at days 1, 3 and 7 and urine KIM-1 levels in both AKI patients and controls were examined. The obtained results were correlated with the AKI stage, duration of renal replacement therapy (RRT) and prognosis.

resultsSerum SP-D level in AKI patients was higher than controls (p < 0.01). SP-D 11Thr/Thr genotype was more frequent in AKI patients than in controls (p < 0.01). Furthermore, AKI patients with SP-D 11Thr/Thr genotype had significantly higher serum SP-D levels (p < 0.05) compared to other genotypes. Serum SP-D levels corrected to the progression of AKI with a peak at day 3. Furthermore, the SP-D 11Thr/Thr genotype frequency and baseline serum SP-D level were higher in patients who subsequently died. Baseline serum SP-D levels positively correlated with the urine KIM-1 levels, AKI stage and RRT duration.

conclusionIn our study, elevated serum SP-D was associated with worse AKI clinical outcomes and patients with SP-D 11Thr/Thr genotype were more susceptible to AKI. Collectively, these findings suggest that SP-D may be useful as a biomarker of AKI susceptibility and prognosis.

Indexed as

Acute Kidney InjuryAdultAsian PeopleCase-Control StudiesChinaFemaleGenetic Predisposition to DiseaseHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedPolymorphism, GeneticPrognosisPulmonary Surfactant-Associated Protein DRenal Replacement TherapySeverity of Illness IndexHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Pulmonary Surfactant-Associated Protein DAcute kidney injuryKidney injury molecule-1PolymorphismPrognosisSurfactant protein DSusceptibility

Identifiers

PMID28212617
PMCPMC5316147
OpenAlexW2588150721

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.