ArticleBMC medical genetics2017
African ancestry is associated with facial melasma in women: a cross-sectional study.
Article in BMC medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Prevalence of depression in melasma: a systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Photoaging: Update on Pathogenesis, Prevention, and Treatment.Annals of dermatology · 2026Review
- A Study of Factors Associated With Melasma and Quality of Life in Patients With Melasma: A Case-Control Study.Cureus · 2026Article
- Association of Genetic Polymorphisms in SLC45A2, TYR, HERC2, and SLC24A in African Women with Melasma: A Pilot Study.International journal of molecular sciences · 2025Article
- The Effect of Melasma on the Quality of Life in People with Darker Skin Types Living in Durban, South Africa.International journal of environmental research and public health · 2023Article
- Melasma in people with darker skin types: a scoping review protocol on prevalence, treatment options for melasma and impact on quality of life.Systematic reviews · 2023Article
- New Mechanistic Insights of Melasma.Clinical, cosmetic and investigational dermatology · 2023Review
- Update on Melasma-Part I: Pathogenesis.Dermatology and therapy · 2022Review
- Analysis of ordinal data in clinical and experimental studies.Jornal vascular brasileiro · 2020Article
- Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin.Annals of dermatology · 2020Article
- Clinical manifestations and quality of life in hidradenitis suppurativa patients: survey of participants from an internet support group.Anais brasileiros de dermatologia · 2019Article
- The potential European genetic predisposition for non-contact anterior cruciate ligament injury.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study.BMC dermatology · 2017Article
- Comparison of efficacy of Tranexamic Acid Mesotherapy versus 0.9% normal Saline for Melasma; A split face study in a Tertiary Care Hospital of Karachi.Pakistan journal of medical sciencesArticle
- Evaluation of ex vivo melanogenic response to UVB, UVA, and visible light in facial melasma and unaffected adjacent skin.Anais brasileiros de dermatologiaArticle
- Profile of dermatological consultations in Brazil (2018).Anais brasileiros de dermatologiaArticle
- Impact of environmental changes on Dermatology.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMelasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma.
methodsA cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed. DNA was extracted from oral mucosa swabs and ancestry determined by studying 61 INDELs. The genetic ancestry components were adjusted by other known risk factors by multiple logistic regression.
resultsWe evaluated 119 women with facial melasma and 119 controls. Mean age was 39 ± 9 years. Mean age at beginning of disease was 27 ± 8 years. Pregnancy (40%), sun exposure (37%), and hormonal oral contraception (22%) were the most frequently reported melasma triggers. All subjects presented admixed ancestry, African and European genetic contributions were significantly different between cases and controls (respectively 10% vs 6%; 77% vs 82%; p < 0.05). African ancestry (OR = 1.04; 95% CI 1.01 to 1.07), first generation family history (OR = 3.04; 95% CI 1.56 to 5.94), low education level (OR = 4.04; 95% CI 1.56 to 5.94), and use of antidepressants by individuals with affected family members (OR = 6.15; 95% CI 1.13 to 33.37) were associated with melasma, independently of other known risk factors.
conclusionsFacial melasma was independently associated with African ancestry in a highly admixed population.
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