ArticlePloS one2017
Risk factors for central nervous system tumors in children: New findings from a case-control study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Global, regional, and national burden of brain and central nervous system cancer in children and adolescents, 1990-2021: A systematic analysis of the Global Burden of Disease study 2021.Pediatric investigation · 2025Article
- The comparative burden of brain and central nervous system cancers from 1990 to 2021 between China, the United States, the United Kingdom, and Japan.BMC public health · 2025Article
- Air pollution and its impact on cancer incidence, cancer care and cancer outcomes.BMJ oncology · 2025Review
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Socio-demographic and antenatal risk factors of brain tumor in children and young people: A matched case-control study from Karachi, Pakistan.Journal of public health research · 2023Article
- The comparative burden of brain and central nervous system cancers from 1990 to 2019 between China and the United States and predicting the future burden.Frontiers in public health · 2022Article
- The need for a central brain tumor registry in Africa: A review of central nervous system tumors in Africa from 1960 to 2017.Neuro-oncology practice · 2021Article
- Socioeconomic differences in the risk of childhood central nervous system tumors in Denmark: a nationwide register-based case-control study.Cancer causes & control : CCC · 2020Article
- Bayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: a nationwide study during 1985-2015.International journal of health geographics · 2020Article
- Methodological approaches to the study of cancer risk in the vicinity of pollution sources: the experience of a population-based case-control study of childhood cancer.International journal of health geographics · 2019Article
- Circular RNA expression profiles during the differentiation of mouse neural stem cells.BMC systems biology · 2018Article
- Article
- Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis.Neuro-oncology advancesArticle
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral nervous system tumors (CNS) are the most frequent solid tumor in children. Causes of CNS tumors are mainly unknown and only 5% of the cases can be explained by genetic predisposition. We studied the effects of environmental exposure on the incidence of CNS tumors in children by subtype, according to exposure to industrial and/or urban environment, exposure to crops and according to socio-economic status of the child.
methodsWe carried out a population-based case-control study of CNS tumors in Spain, covering 714 incident cases collected from the Spanish Registry of Childhood Tumors (period 1996-2011) and 4284 controls, individually matched by year of birth, sex, and autonomous region of residence. We built a covariate to approximate the exposure to industrial and/or urban environment and a covariate for the exposure to crops (GCI) using the coordinates of the home addresses of the children. We used the 2001 Census to obtain information about socio-economic status (SES). We fitted logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs).
resultsThe results for all CNS tumors showed an excess risk (OR = 1.37; 95%CI = 1.09-1.73) for SES, i.e., children living in the least deprived areas had 37% more risk of CNS tumor than children living in the most deprived areas. For GCI, an increase of 10% in crop surface in the 1-km buffer around the residence implied an increase of 22% in the OR (OR = 1.22; 95%CI = 1.15-1.29). Children living in the intersection of industrial and urban areas could have a greater risk of CNS tumors than children who live outside these areas (OR = 1.20; 95%CI = 0.82-1.77). Living in urban areas (OR = 0.90; 95%CI = 0.65-1.24) or industrial areas (OR = 0.96; 95%CI = 0.81-1.77) did not seem to increase the risk for all CNS tumors together. By subtype, Astrocytomas, Intracranial and intraspinal embryonal tumors, and other gliomas showed similar results.
conclusionOur results suggest that higher socioeconomic status and exposure to crops could increase the risk of CNS tumors in children.
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