ArticlePloS one2017
A mathematical model of aortic aneurysm formation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Data-driven causal model discovery and personalized prediction in Alzheimer's disease.NPJ digital medicine · 2022Article
- A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice.Journal of personalized medicine · 2022Article
- Neutrophils as Regulators and Biomarkers of Cardiovascular Inflammation in the Context of Abdominal Aortic Aneurysms.Biomedicines · 2021Review
- Predicting the risk of rupture for vertebral aneurysm based on geometric features of blood vessels.Royal Society open science · 2021Article
- Surface-directed engineering of tissue anisotropy in microphysiological models of musculoskeletal tissue.Science advances · 2021Article
- Analysis of a mathematical model of rheumatoid arthritis.Journal of mathematical biology · 2020Article
- Mathematical Modelling for the Role of CD4Computational and mathematical methods in medicine · 2020Article
- Arterial Hypertension and Unusual Ascending Aortic Dilatation in a Neonate With Acute Kidney Injury: Mechanistic Computer Modeling.Frontiers in physiology · 2019Article
- Vertebral artery fusiform aneurysm geometry in predicting rupture risk.Royal Society open science · 2018Article
- Screening Older Adult Men for Abdominal Aortic Aneurysm: A Scoping Review.American journal of men's healthArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta, such that the diameter exceeds 3 cm. The natural history of AAA is progressive growth leading to rupture, an event that carries up to 90% risk of mortality. Hence there is a need to predict the growth of the diameter of the aorta based on the diameter of a patient's aneurysm at initial screening and aided by non-invasive biomarkers. IL-6 is overexpressed in AAA and was suggested as a prognostic marker for the risk in AAA. The present paper develops a mathematical model which relates the growth of the abdominal aorta to the serum concentration of IL-6. Given the initial diameter of the aorta and the serum concentration of IL-6, the model predicts the growth of the diameter at subsequent times. Such a prediction can provide guidance to how closely the patient's abdominal aorta should be monitored. The mathematical model is represented by a system of partial differential equations taking place in the aortic wall, where the media is assumed to have the constituency of an hyperelastic material.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.