ArticlePloS one2017
Plants promote mating and dispersal of the human pathogenic fungus Cryptococcus.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Genomic hallmarks of parasexual reproduction in three hybrid groups of the human pathogenbioRxiv : the preprint server for biology · 2026Article
- Pathogenicity and virulence of Cryptococcus neoformans from an environmental perspective.Virulence · 2025Review
- Article
- Influence of the agrochemical benomyl on Cryptococcus gattii-plant interaction in vitro and in vivo.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- A trade-off between proliferation and defense in the fungal pathogenbioRxiv : the preprint server for biology · 2024Article
- Biogenesis, germination, and pathogenesis ofMicrobiology and molecular biology reviews : MMBR · 2024Review
- A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans.PLoS pathogens · 2023Article
- Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections.Pharmaceutics · 2023Review
- Last but not yeast-The many forms of Cryptococcus neoformans.PLoS pathogens · 2023Article
- A Possible Link between the Environment andInternational journal of environmental research and public health · 2022Article
- Search forJournal of fungi (Basel, Switzerland) · 2022Article
- Cryptococcus neoformans melanization incorporates multiple catecholamines to produce polytypic melanin.The Journal of biological chemistry · 2022Article
- I Like the Way You Eat It: Lemur (Indri indri) Gut Mycobiome and Geophagy.Microbial ecology · 2021Article
- Combining natural language processing and metabarcoding to reveal pathogen-environment associations.PLoS neglected tropical diseases · 2021Article
- Cryptococcus in Wildlife and Free-Living Mammals.Journal of fungi (Basel, Switzerland) · 2021Review
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- First Isolation, Antifungal Susceptibility, and Molecular Characterization ofJournal of fungi (Basel, Switzerland) · 2019Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Infections due to Cryptococcus are a leading cause of fungal infections worldwide and are acquired as a result of environmental exposure to desiccated yeast or spores. The ability of Cryptococcus to grow, mate, and produce infectious propagules in association with plants is important for the maintenance of the genetic diversity and virulence factors important for infection of animals and humans. In the Western United States and Canada, Cryptococcus has been associated with conifers and tree species other than Eucalyptus; however, to date Cryptococcus has only been studied on live Arabidopsis thaliana, Eucalyptus sp., and Terminalia catappa (almond) seedlings. Previous research has demonstrated the ability of Cryptococcus to colonize live plants, leaves, and vasculature. We investigated the ability of Cryptococcus to grow on live seedlings of the angiosperms, A. thaliana, Eucalyptus camaldulensis, Colophospermum mopane, and the gymnosperms, Pseudotsuga menziesii (Douglas fir), and Tsuga heterophylla (Western hemlock). We observed a broad-range ability of Cryptococcus to colonize both traditional infection models as well as newly tested conifer species. Furthermore, C. neoformans, C. deneoformans, C. gattii (VGI), C. deuterogattii (VGII) and C. bacillisporus (VGIII) were able to colonize live plant leaves and needles but also undergo filamentation and mating on agar seeded with plant materials or in saprobic association with dead plant materials. The ability of Cryptococcus to grow and undergo filamentation and reproduction in saprobic association with both angiosperms and gymnosperms highlights an important role of plant debris in the sexual cycle and exposure to infectious propagules. This study highlights the broad importance of plants (and plant debris) as the ecological niche and reservoirs of infectious propagules of Cryptococcus in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.