ArticleScientific reports2017
A 'selfish' B chromosome induces genome elimination by disrupting the histone code in the jewel wasp Nasonia vitripennis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Heterochromatin protein 1 (HP1) dysfunction drives male-biased sex ratio in Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) via paternal genome elimination during mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- Chromatin state dynamics of autosomes and the B chromosome during spermatogenesis in Pseudococcus viburni.Heredity · 2026Article
- Horizontal transfer of accessory chromosomes in fungi - a regulated process for exchange of genetic material?Heredity · 2026Review
- The enigma of the B chromosome-specific behaviour.Frontiers in plant science · 2026Review
- Telomere-to-telomere Phragmites australis reference genome assembly with a B chromosome provides insights into its evolution and polysaccharide biosynthesis.Communications biology · 2025Article
- Frequent horizontal chromosome transfer between asexual fungal insect pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gametocidal genes: from a discovery to the application in wheat breeding.Frontiers in plant science · 2024Review
- Ability of a selfish B chromosome to evade genome elimination in the jewel wasp, Nasonia vitripennis.Heredity · 2023Article
- Meiotic behavior, transmission and active genes of B chromosomes in the cichlid Astatotilapia latifasciata: new clues about nature, evolution and maintenance of accessory elements.Molecular genetics and genomics : MGG · 2022Article
- Sperm Limitation Produces Male Biased Offspring Sex Ratios in the Wasp, Nasonia vitripennis (Hymenoptera: Pteromalidae).Journal of insect science (Online) · 2022Article
- Delete and survive: strategies of programmed genetic material elimination in eukaryotes.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Linked supergenes underlie split sex ratio and social organization in an ant.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mechanistically comparing reproductive manipulations caused by selfish chromosomes and bacterial symbionts.Heredity · 2021Review
- Genome elimination mediated by gene expression from a selfish chromosome.Science advances · 2020Article
- Hybridization promotes asexual reproduction in Caenorhabditis nematodes.PLoS genetics · 2019Article
- Spermatogenesis in haploid males of the jewel wasp Nasonia vitripennis.Scientific reports · 2019Article
- Dissecting the Complex Genome of Crested Wheatgrass by Chromosome Flow Sorting.The plant genome · 2019Article
- Review
- Article
- Embryo Microinjection and Transplantation Technique for Nasonia vitripennis Genome Manipulation.Journal of visualized experiments : JoVE · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intragenomic conflict describes a phenomenon in which genetic elements act 'selfishly' to gain a transmission advantage at the expense of the whole genome. A non-essential, selfish B chromosome known as Paternal Sex Ratio (PSR) induces complete elimination of the sperm-derived hereditary material in the jewel wasp Nasonia vitripennis. PSR prevents the paternal chromatin from forming chromosomes during the first embryonic mitosis, leading to its loss. Although paternally transmitted, PSR evades self-elimination in order to be inherited. We examined important post-translational modifications to the DNA packaging histones on the normal genome and the PSR chromosome in the fertilized embryo. Three histone marks - H3K9me2,3, H3K27me1, and H4K20me1 - became abnormally enriched and spread to ectopic positions on the sperm's chromatin before entry into mitosis. In contrast, other histone marks and DNA methylation were not affected by PSR, suggesting that its effect on the paternal genome is specific to a subset of histone marks. Contrary to the paternally derived genome, the PSR chromosome was visibly devoid of the H3K27me1 and H4K20me1 marks. These findings strongly suggest that PSR causes paternal genome elimination by disrupting at least three histone marks following fertilization, while PSR avoids self-elimination by evading two of these marks.
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