ArticleeLife2017
The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- Interoceptive ability is uncorrelated across respiratory and cardiac axes in a large scale psychophysical study.Communications psychology · 2026Article
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Neural correlates underlying high-frequency stimulation-induced secondary hyperalgesia in humans.Pain reports · 2025Article
- High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Therapy in Amyotrophic Lateral Sclerosis: Study Protocol for a Multicenter Randomized Controlled Clinical Trial.Journal of clinical medicine · 2025Article
- Microstructural Brain Correlates of Inter-individual Differences in Respiratory Interoception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024Article
- The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.Frontiers in neuroscience · 2024Review
- The bidirectional relationship between the cerebellum and seizure networks: a double-edged sword.Current opinion in behavioral sciences · 2023Article
- Cerebellar mutism is linked to midbrain volatility and desynchronization from speech cortices.Brain : a journal of neurology · 2023Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Intrinsic brain connectivity alterations despite intact pain inhibition in subjects with neuropathic pain after spinal cord injury: a pilot study.Scientific reports · 2023Article
- Effect of listening to breathing recordings on self-reported breathlessness: a public experiment.The European respiratory journal · 2023Article
- Functional connectivity between interoceptive brain regions is associated with distinct health-related domains: A population-based neuroimaging study.Human brain mapping · 2023Article
- Orchestration of innate and conditioned defensive actions by the periaqueductal gray.Neuropharmacology · 2023Review
- Ventrolateral periaqueductal gray matter integrative system of defense and antinociception.Pflugers Archiv : European journal of physiology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Previously we observed differential activation in individual columns of the periaqueductal grey (PAG) during breathlessness and its conditioned anticipation (Faull et al., 2016b). Here, we have extended this work by determining how the individual columns of the PAG interact with higher cortical centres, both at rest and in the context of breathlessness threat. Activation was observed in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scaled with breathlessness intensity ratings, revealing a potential interface between sensation and cognition during breathlessness. At rest the lPAG was functionally correlated with cortical sensorimotor areas, conducive to facilitating fight/flight responses, and demonstrated increased synchronicity with the amygdala during breathlessness. The vlPAG showed fronto-limbic correlations at rest, whereas during breathlessness anticipation,
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