ArticleNature communications2017
Arylmethylamino steroids as antiparasitic agents.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
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- Arylmethylamino steroid compound 1o interferes withAntimicrobial agents and chemotherapy · 2025Article
- "Seasoning" antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits.RSC medicinal chemistry · 2024Article
- High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.Journal of medicinal chemistry · 2023Article
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- Naturally Occurring Cardenolides AffectingACS infectious diseases · 2020Article
- In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o.Scientific reports · 2020Article
- Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis.ACS infectious diseases · 2020Article
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Corrections and comments
- Erratum issued
Authors and funding
20 authors at 9 institutions in 4 countries.
Reimar KriegInstitute of Anatomy II, University Hospital Jena, Teichgraben 7, 07743 Jena, Germany.
Esther JortzikBiochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen, Heinrich Buff Ring 26-32, 35392 Giessen, Germany.
Alice-Anne GoetzUniversité de Strasbourg, CNRS, Inserm, MIR UPR9022/U963, F-67000 Strasbourg, France.
Stéphanie BlandinUniversité de Strasbourg, CNRS, Inserm, MIR UPR9022/U963, F-67000 Strasbourg, France.
Sergio WittlinSwiss Tropical and Public Health Institute, Socinstrasse 57, PO Box, 4002 Basel, Switzerland.
Mourad ElhabiriUMR 7509 Centre National de la Recherche Scientifique and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM), 25, rue Becquerel, F-67087 Strasbourg, France.
Mahsa RahbariBiochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen, Heinrich Buff Ring 26-32, 35392 Giessen, Germany.
Selbi NuryyevaUMR 7509 Centre National de la Recherche Scientifique and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM), 25, rue Becquerel, F-67087 Strasbourg, France.
Kerstin VoigtLeibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Adolf-Reichwein-Strasse 23, 07745 Jena, Germany.
Hans-Martin DahseLeibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Adolf-Reichwein-Strasse 23, 07745 Jena, Germany.
Axel BrakhageLeibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Adolf-Reichwein-Strasse 23, 07745 Jena, Germany.
Svenja BeckmannInstitute of Parasitology, Biomedical Research Centre, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany.
Thomas QuackInstitute of Parasitology, Biomedical Research Centre, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany.
Christoph G GreveldingInstitute of Parasitology, Biomedical Research Centre, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany.
Anthony B PinkertonConrad Prebys Center for Chemical Genomics, Sanford-Burnham-Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Bruno SchöneckerInstitute of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany.
Jeremy BurrowsMedicines for Malaria Venture, 20 Route de Pré-Bois, 1215 Geneva 15, Switzerland.
Elisabeth Davioud-CharvetUMR 7509 Centre National de la Recherche Scientifique and University of Strasbourg, European School of Chemistry, Polymers and Materials (ECPM), 25, rue Becquerel, F-67087 Strasbourg, France.
Stefan RahlfsBiochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen, Heinrich Buff Ring 26-32, 35392 Giessen, Germany.
Katja BeckerBiochemistry and Molecular Biology, Interdisciplinary Research Centre, Justus Liebig University Giessen, Heinrich Buff Ring 26-32, 35392 Giessen, Germany.
University of Giessen · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversité de Strasbourg · FRInserm · FRDiscovery Institute · USFriedrich Schiller University Jena · DEJena University Hospital · DEMedicines for Malaria Venture · CHUniversity of Basel · CH
Funding
European Research Council 260918
Abstract
In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC
Indexed as
AminesAnimalsAnophelesAnti-Infective AgentsAntiparasitic AgentsCell DeathCell ProliferationFemaleGerm CellsInhibitory Concentration 50Life Cycle StagesMalariaMiceModels, BiologicalParasitesPlasmodium bergheiAminesAnti-Infective AgentsAntiparasitic AgentsSteroids
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.