ArticleScientific reports2017
Differences in the Clinical Characteristics of Early- and Late-Onset Necrotizing Enterocolitis in Full-Term Infants: A Retrospective Case-Control Study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Study of the gut microbiome profile in full-term infants with necrotizing enterocolits.World journal of clinical pediatrics · 2026Article
- Validation of a Predictive Nomogram for Mortality Among Neonates With Necrotizing Enterocolitis in Tertiary Care Hospitals at Bahir Dar City, Bahir Dar, Northwest Ethiopia.Clinical medicine insights. Pediatrics · 2026Article
- Clinical characteristics of necrotizing enterocolitis occurring within the first week of life in low-birth-weight preterm infants: a multicenter retrospective study.Frontiers in medicine · 2026Article
- Necrotizing Enterocolitis in Term Neonates: A Retrospective Chart Review from Children's Medical Center, Tehran (2020-2023).Archives of Iranian medicine · 2025Article
- Optimal Closure Timing for Protective Jejunostomy in an Infant with Necrotizing Enterocolitis: A Case Report.The American journal of case reports · 2025Article
- Review
- Exploring the predictive value of pH in stratified mortality risk of NEC patients undergoing surgery: a retrospective study based on the PIC database.Translational pediatrics · 2025Article
- Evaluation of gestational age, serum amyloid A, and hemoglobin decline (ΔHb) as diagnostic markers for NEC secondary to late-onset sepsis in preterm infants.Frontiers in pediatrics · 2025Article
- A time series algorithm to predict surgery in neonatal necrotizing enterocolitis.BMC medical informatics and decision making · 2024Article
- Early versus late-onset necrotizing enterocolitis in very low birth infants in the neonatal intensive care unit.Pediatric surgery international · 2022Article
- Clinical Laboratory Features of Microbes That Cause Neonatal Sepsis: An 8-Year Retrospective Study.Infection and drug resistance · 2022Article
- Association of neutropenia at disease onset with severe surgical necrotizing enterocolitis and higher mortality: A retrospective study.Frontiers in surgery · 2022Article
- It's all in the milk: chondroitin sulfate as potential preventative therapy for necrotizing enterocolitis.Pediatric research · 2021Review
- The association between enteric viruses and necrotizing enterocolitis.European journal of pediatrics · 2021Article
- Specific imaging features of intestinal perforation on supine abdominal X-ray evaluation in infants with necrotizing enterocolitis.World journal of pediatric surgery · 2021Article
- Challenges in diagnosing necrotizing enterocolitis.Pediatric research · 2020Review
- Fulminant Necrotizing Enterocolitis and Multiple Organ Dysfunction in a Toddler with Mitochondrial DNA Depletion Syndrome-13.Journal of pediatric intensive care · 2020Article
- Human β-defensin-3 reduces excessive autophagy in intestinal epithelial cells and in experimental necrotizing enterocolitis.Scientific reports · 2019Article
- Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis.Journal of pediatric surgery · 2019Article
- Early onset necrotising enterocolitis in association with congenital diaphragmatic hernia in a term baby.BMJ case reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information regarding the influence of age at onset on prognosis in full-term infants with necrotizing enterocolitis (NEC) is limited, and identifying differences between the clinical characteristics of early-onset NEC (EO-NEC) and late-onset NEC (LO-NEC) may be helpful in the determination of effective management strategies. In the present study, the medical records of 253 full-term infants with NEC were reviewed, and the clinical characteristics of the EO-NEC group (n = 150) and the LO-NEC group (n = 103) were compared. Infants in the EO-NEC group were characterized by increased gestational age and higher rates of stage III NEC and peritonitis when compared with LO-NEC infants (P < 0.05). Mortality was significantly associated with stage III NEC, peritonitis, sepsis, respiratory failure and shock in univariate analysis (P < 0.05). In logistic regression analysis, peritonitis and renal failure were identified as independent risk factors for mortality in infants with EO-NEC, and peritonitis and respiratory failure were significant predictors of mortality in neonates with LO-NEC. Our finding indicated that the characteristics of the severe medical conditions identified in infants with EO-NEC were distinct from those observed in infants with LO-NEC. Peritonitis and kidney failure and peritonitis and respiratory failure were identified as risk factors for mortality in EO-NEC and LO-NEC infants, respectively.
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