ArticleJournal of nephrology2017
Infectious complications as the leading cause of death after kidney transplantation: analysis of more than 10,000 transplants from a single center.
Article in Journal of nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Comparison of outcomes of peritoneal dialysis between patients after failed kidney transplant and transplant-naïve patients: a meta-analysis of observational studies.Renal failure · 2021Pooled it
- Trial
- Outcomes of Kidney Transplants From Standard Criteria Donors With Diabetes: A Propensity Score-Matched Study.Kidney medicine · 2026Article
- A scoping review of risk factors for urinary tract infections following renal transplantation.BMC urology · 2026Article
- [Experience summary of robot-assisted laparoscopic transplant nephrectomy].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Persistent Mortality Risk From Device-related Healthcare-associated Infection in Kidney Transplant Recipients Despite Multifaceted Interventions Action Calls for a Zero-tolerance Policy.Transplantation direct · 2025Article
- Infections in Kidney Transplant Recipients: Perspectives in French Caribbean.Microorganisms · 2024Article
- Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single-center retrospective cohort study.Endocrine · 2024Article
- Torquetenovirus Viremia Quantification Using Real-Time PCR Developed on a Fully Automated, Random-Access Platform.Viruses · 2024Article
- Peritoneal dialysis after failed kidney allograft: Comparing patients with and without pd before transplant.PloS one · 2023Review
- Regulation of gut microbiota: a novel pretreatment for complications in patients who have undergone kidney transplantation.Frontiers in cellular and infection microbiology · 2023Review
- Tropical Infections in the Context of Kidney Transplantation in Latin America.The American journal of tropical medicine and hygiene · 2021Review
- A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders.Journal of translational medicine · 2021Article
- The urinary microbiome shows different bacterial genera in renal transplant recipients and non-transplant patients at time of acute kidney injury - a pilot study.BMC nephrology · 2020Article
- Early Hospital Readmission (EHR) in kidney transplantation: a review article.Jornal brasileiro de nefrologia · 2020Review
- Impact of Combinations of Donor and Recipient Ages and Other Factors on Kidney Graft Outcomes.Frontiers in immunology · 2020Article
- Clinical outcomes of incident peritoneal dialysis patients coming from kidney transplantation program: A case-control study.PloS one · 2020Article
- Frailty predicts surgical complications after kidney transplantation. A propensity score matched study.PloS one · 2020Article
- Updates on urinary tract infections in kidney transplantation.Journal of nephrology · 2019Review
- Impact of Pneumocystis jirovecii pneumonia on kidney transplant outcome.BMC nephrology · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify specific causes of graft failure in a large sample of kidney transplant patients from a middle-income, developing country.
methodsRetrospective cohort study analyzing all consecutive single kidney transplants (KTs) performed at a single center in Brazil between January 1st 1998 and December 31st 2013. The database closing date was December 31st 2014.
resultsOut of 10,400 KTs, there were 1191 (11.45%) deaths with a functioning graft, 40 cases (0.38%) of primary non-function (PNF) and 1417 cases (13.62%) of graft loss excluding death and PNF as the cause. Infectious complications (404 cases, 34% of all deaths) were the major cause of death. Most deaths due to infection occurred within the first year after transplantation (157 deaths, 38.86%). Immunologic mechanisms, comprising acute rejection and immune-mediated interstitial fibrosis/tubular atrophy (IF/TA), were responsible for 52% of all cases of graft failure not involving recipient death. Half of the losses by acute rejection occurred late after transplantation.
conclusionContrary to what is observed in developed countries, infectious complications are the main challenge with kidney transplantation in Brazil. Non-adherence to treatment also appears to contribute significantly to long-term kidney graft loss. Strategies for improvement should focus on better compliance and a greater safety profile of immunosuppressive treatment.
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