Evidence map›Paper›PMID 28210997›Full record

ArticleEJNMMI research2017

3D skeletal uptake of

Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H Poulsen, Mattias Ohlsson and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Article
  8. Global disease score (GDS) is the name of the game!European journal of nuclear medicine and molecular imaging · 2019
    Article
  9. Article
  10. Article
  11. Review
  12. Uptake of Radium-223 Dichloride and Early [Molecular imaging and biology · 2018
    Article
  13. Functional and Hybrid Imaging of Bone Metastases.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Review
  14. Hospice Admission and Survival AfterJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Sarah Lindgren BelalDepartment of Translational Medicine, Lund University, Malmö, Sweden. sarah.lindgren_belal@med.lu.se.
May SadikDepartment of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden.
Reza KabotehDepartment of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden.
Nezar HasaniDepartment of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden.
Olof EnqvistDepartment of Signals and Systems, Chalmers University of Technology, Göteborg, Sweden.
Linus SvärmEigenvision AB, Malmö, Sweden.
Fredrik KahlDepartment of Signals and Systems, Chalmers University of Technology, Göteborg, Sweden.
Jane SimonsenDepartment of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
Mads H PoulsenDepartment of Urology, Odense University Hospital, Odense, Denmark.
Mattias OhlssonDepartment of Astronomy and Theoretical Physics, Lund University, Lund, Sweden.
Poul F Høilund-CarlsenDepartment of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
Lars EdenbrandtDepartment of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden.
Elin TrägårdhDepartment of Translational Medicine, Lund University, Malmö, Sweden.
Sahlgrenska University Hospital · SELund University · SEOdense University Hospital · DKChalmers University of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer.

methodsNaF PET/CT and bone scans were studied in 48 patients with prostate cancer. Automated segmentation of the thoracic and lumbar spines, sacrum, pelvis, ribs, scapulae, clavicles, and sternum were made in the CT images. Hotspots in the PET images were selected using both a manual and an automated method. The volume of each hotspot localized in the skeleton in the corresponding CT image was calculated. Two PET/CT indices, based on manual (manual PET index) and automatic segmenting using a threshold of SUV 15 (automated PET

resultsBSI, manual PET index, and automated PET

conclusionsPET/CT indices based on NaF PET/CT are correlated to BSI and significantly associated with overall survival in patients with prostate cancer.

Indexed as

Bone scan indexImaging biomarkerPET/CTProstate cancerSodium fluoride

Identifiers

PMID28210997
PMCPMC5313492
OpenAlexW2588262604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.