Evidence map›Paper›PMID 28210958›Full record

ReviewNeurochemical research2017

Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

Celia Kjaerby, Rune Rasmussen, Mie Andersen, Maiken Nedergaard

Open access · greenAbstract readReview
In one paragraph

Review in Neurochemical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Cortical astrocytes regulate ethanol consumption and intoxication in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Astrocytic CaNature communications · 2020
    Article
  18. Review
  19. Article
  20. Brain energetics during the sleep-wake cycle.Current opinion in neurobiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Celia KjaerbyCenter for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
Rune RasmussenCenter for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
Mie AndersenCenter for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
Maiken NedergaardCenter for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark. nedergaard@sund.ku.dk.
University of Copenhagen · DK

Funding

Patient-derived iPS cells as model systems for AxDP01HD076892 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI NEDERGAARD, MAIKEN · 2014 to 2018
$6.0M
Para-Vascular Basis of Small Vessel DiseaseR01NS100366 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2016 to 2020
$3.8M
Characterizing the glymphatic peri-vascular connectome and its disruption in ADRF1AG053991 · NIA · YALE UNIVERSITY · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2016 to 2016
$3.4M
Hemichannels, Astrocytic Release, and Neuropathic PainR01DE022743 · NIDCR · DUKE UNIVERSITY · PI JI, RU-RONG, NEDERGAARD, MAIKEN · 2012 to 2016
$2.0M
Failure of metabolite clearance in a model of multi-lacunar infarctsR01NS078167 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2012 to 2016
$1.8M
The glymphatic system, a new concept in glia biologyR01NS078304 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2012 to 2016
$1.7M
ATP as the instigator of inflammatory responses to spinal cord injuryR01NS075177 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2012 to 2016
$1.6M
Glymphatic function in a transgenic rat model of Alzheimer's diseaseR01AG048769 · NIA · UNIVERSITY OF ROCHESTER · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2014 to 2018
$1.4M
NIA NIH HHS R01 AG048769NIA NIH HHS RF1 AG053991NICHD NIH HHS P01 HD076892NIDCR NIH HHS R01 DE022743NINDS NIH HHS R01 NS075177NINDS NIH HHS R01 NS078167NINDS NIH HHS R01 NS078304NINDS NIH HHS R01 NS100366
6 · The paper itself

Abstract

We continuously need to adapt to changing conditions within our surrounding environment, and our brain needs to quickly shift between resting and working activity states in order to allow appropriate behaviors. These global state shifts are intimately linked to the brain-wide release of the neuromodulators, noradrenaline and acetylcholine. Astrocytes have emerged as a new player participating in the regulation of brain activity, and have recently been implicated in brain state shifts. Astrocytes display global Ca

Indexed as

AnimalsAstrocytesBrainCalcium SignalingHumansNerve NetNeuronsNeurotransmitter AgentsWakefulnessNeurotransmitter AgentsAstrocytesBrain stateCalciumNeuronal circuitWakefulness

Identifiers

PMID28210958
PMCPMC5451293
OpenAlexW2588320379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.