Evidence map›Paper›PMID 28210899›Full record

Trial reportMolecular and cellular biochemistry2017

Interleukin-6 as possible early marker of stress response after femoral fracture.

Goran Pesic, Jovana Jeremic, Tamara Nikolic, Vladimir Zivkovic, Ivan Srejovic, Aleksandra Vranic, Jovana Bradic, Branko Ristic, Aleksandar Matic, Nikola Prodanovic and 1 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. [Perioperative changes of serum interleukin 6 levels in elderly male patients with intertrochanteric fracture].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Article
  3. Article
  4. Inflamm-Aging-Related Cytokines of IL-17 and IFN-Journal of immunology research · 2021
    Article
  5. Article
  6. The Role of the Immune Microenvironment in Bone Regeneration.International journal of medical sciences · 2021
    Review
  7. Article
  8. Article
  9. Observational
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Goran PesicOrthopedic and Traumatology Clinic, Podgorica, Montenegro.
Jovana JeremicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Tamara NikolicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Vladimir ZivkovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Ivan SrejovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Aleksandra VranicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Jovana BradicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Branko RisticClinic of Orthopedic Surgery, Clinical Center of Kragujevac, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Aleksandar MaticClinic of Orthopedic Surgery, Clinical Center of Kragujevac, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Nikola ProdanovicClinic of Orthopedic Surgery, Clinical Center of Kragujevac, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Vladimir JakovljevicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia. drvladakgbg@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone fracture healing is a complex process which at best results in full recovery of function and structure of injured bone tissue, but all the mechanisms involved in this process, and their mutual interaction, are not fully understood. Despite advancement of surgical procedures, this type of fractures is still a major public health concern. In the last few decades, a lot of attention is focused on the oxygen-free radicals and inflammatory response markers as important factors of skeletal injury. Thus, the aim of the present study was to follow the changes in redox balance and inflammatory response in elderly patients with femoral fractures during the earliest stages of fracture healing, by measuring the values of the observed markers immediately after fracture, as well as the first, third, and seventh postoperative day. Present study was performed on a group of 65 elderly patients with femoral neck fractures, recruited from the Orthopedic Clinic, Clinical Centre Kragujevac in the period from February to May 2015. Redox status was measured spectrophotometrically and evaluated by measuring the levels of index of lipid peroxidation (measured as TBARS), nitrite (NO

Indexed as

AgedAged, 80 and overBiomarkersFemaleFemoral FracturesHumansInterleukin-6MaleNitritesSuperoxidesThiobarbituric Acid Reactive SubstancesTumor Necrosis Factor-alphaBiomarkersIL6 protein, humanInterleukin-6NitritesSuperoxidesThiobarbituric Acid Reactive SubstancesTumor Necrosis Factor-alphaAntioxidative enzymesFemoral fractureInterleukin-6Oxidative stressRedox statusTumor necrosis factor alpha

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.