Evidence map›Paper›PMID 28210851›Full record

ArticleInternational journal of colorectal disease2017

In vivo and ex vivo sentinel node mapping does not identify the same lymph nodes in colon cancer.

Helene Schou Andersen, Astrid Louise Bjørn Bennedsen, Stefan Kobbelgaard Burgdorf, Jens Ravn Eriksen, Susanne Eiholm, Anders Toxværd, Lene Buhl Riis, Jacob Rosenberg, Ismail Gögenur

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In one paragraph

Article in International journal of colorectal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  15. Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022
    Review
  16. Fluorescent Tracers forFrontiers in pharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Helene Schou AndersenZealand University Hospital, Copenhagen University, Lykkebækvej 1, 4600, Køge, Denmark. helene@ksandersen.dk.
Astrid Louise Bjørn BennedsenZealand University Hospital, Copenhagen University, Lykkebækvej 1, 4600, Køge, Denmark.
Stefan Kobbelgaard BurgdorfRigshospitalet, Blegdamsvej 9, 2100, København Ø, Denmark.
Jens Ravn EriksenZealand University Hospital, Copenhagen University, Lykkebækvej 1, 4600, Køge, Denmark.
Susanne EiholmZealand University Hospital, Copenhagen University, Lykkebækvej 1, 4600, Køge, Denmark.
Anders ToxværdHerlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
Lene Buhl RiisHerlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
Jacob RosenbergHerlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
Ismail GögenurZealand University Hospital, Copenhagen University, Lykkebækvej 1, 4600, Køge, Denmark.
Zealand University Hospital Køge · DKHerlev Hospital · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIdentification of lymph nodes and pathological analysis is crucial for the correct staging of colon cancer. Lymph nodes that drain directly from the tumor area are called "sentinel nodes" and are believed to be the first place for metastasis. The purpose of this study was to perform sentinel node mapping in vivo with indocyanine green and ex vivo with methylene blue in order to evaluate if the sentinel lymph nodes can be identified by both techniques.

methodsPatients with colon cancer UICC stage I-III were included from two institutions in Denmark from February 2015 to January 2016. In vivo sentinel node mapping with indocyanine green during laparoscopy and ex vivo sentinel node mapping with methylene blue were performed in all patients.

resultsTwenty-nine patients were included. The in vivo sentinel node mapping was successful in 19 cases, and ex vivo sentinel node mapping was successful in 13 cases. In seven cases, no sentinel nodes were identified. A total of 51 sentinel nodes were identified, only one of these where identified by both techniques (2.0%). In vivo sentinel node mapping identified 32 sentinel nodes, while 20 sentinel nodes were identified by ex vivo sentinel node mapping. Lymph node metastases were found in 10 patients, and only two had metastases in a sentinel node.

conclusionPlacing a deposit in relation to the tumor by indocyanine green in vivo or of methylene blue ex vivo could only identify sentinel lymph nodes in a small group of patients.

Indexed as

AdultAgedColonic NeoplasmsDemographyDissectionFemaleHumansLymph NodesMaleMiddle AgedSentinel Lymph Node BiopsyColon cancerIndocyanine greenMethylene blueSentinel node mapping

Identifiers

PMID28210851
OpenAlexW2587870837

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.